Downs D A, Woods J H
Psychopharmacologia. 1975 Jul 23;43(1):13-7. doi: 10.1007/BF00437608.
Intravenous pretreatment with DITA (0.1 - 1.0 mg/kg) decreased the rate of food-reinforcement lever pressing in rhesus monkeys. Response rate decreases were dose-dependent but showed the development of tolerance. Self-administration of DITA was initiated and maintained in each of three monkeys when 30 lever presses were required to produce each injection. Maximal response rate during periods of drug availability was maintained by 0.03 mg/kh/injection while higher and lower doses (0.01 and 0.10 mg/kg/injection) maintained lower response rates. Response rate in periods of food availability immediately preceding drug periods was relatively constant across session; response rate in periods of food availability immediately following drug periods, however, decreased with increasing amounts of drug self-administered. Replication of initial self-administration doses produced results comparable to original determinations in contrast to the tolerance observed with DITA effects upon food-reinforced responding. DITA was about 3 times less potent than d-amphetamine in maintaining response rates in drug periods and in decreasing the rate of subsequent food-reinforced responding.
用DITA（0.1 - 1.0毫克/千克）进行静脉预处理可降低恒河猴按压食物强化杠杆的速率。反应速率的降低呈剂量依赖性，但显示出耐受性的发展。当每次注射需要30次杠杆按压时，三只猴子中的每只都开始并维持了DITA的自我给药。药物可得期间的最大反应速率由0.03毫克/千克/注射维持，而较高和较低剂量（0.01和0.10毫克/千克/注射）维持较低的反应速率。在药物期之前紧接着的食物可得期间的反应速率在整个实验过程中相对恒定；然而，在药物期之后紧接着的食物可得期间的反应速率随着自我给药药物量的增加而降低。与DITA对食物强化反应的耐受性观察结果相反，初始自我给药剂量的重复产生了与原始测定结果相当的结果。在维持药物期的反应速率以及降低随后食物强化反应的速率方面，DITA的效力比右旋苯丙胺低约3倍。
