Abdallah A H, Roby D M, Boeckler W H, Riley C C
Eur J Pharmacol. 1976 Nov;40(1):39-44. doi: 10.1016/0014-2999(76)90351-4.
The effects of d,1-alpha-methyltyrosine (alphaMT), haloperidol, phenoxybenazmine, propranolol, methysergide and cyproheptadine on the anorexigenic activities of DITA and d-amphetamine were studied in male mice. The pretreatment of mice with methysergide (10 mg/kg, s.c.), cyproheptadine (5 mg/kg, i.p.), phenoxybenzamine (10 mg/kg, i.p.), and propranolol (5 mg/kg, i.p.) failed to alter the anorexigenic effect of DITA and d-amphetamine. On the other hand, alphaMT (32 mg/kg, i.p.) and haloperidol (0.5 mg/kg, i.p.) significantly antagonized the anorexigenic effect of DITA and d-amphetamine. Our data indicate that the anorexigenic activities of DITA and d-amphetamine are mediated mainly through the dopaminergic system.
在雄性小鼠中研究了d，1-α-甲基酪氨酸（αMT）、氟哌啶醇、酚苄明、普萘洛尔、麦角新碱和赛庚啶对二乙硫代氨基甲酸酯（DITA）和d-苯丙胺厌食活性的影响。用麦角新碱（10毫克/千克，皮下注射）、赛庚啶（5毫克/千克，腹腔注射）、酚苄明（10毫克/千克，腹腔注射）和普萘洛尔（5毫克/千克，腹腔注射）对小鼠进行预处理，未能改变DITA和d-苯丙胺的厌食作用。另一方面，αMT（32毫克/千克，腹腔注射）和氟哌啶醇（0.5毫克/千克，腹腔注射）显著拮抗DITA和d-苯丙胺的厌食作用。我们的数据表明，DITA和d-苯丙胺的厌食活性主要通过多巴胺能系统介导。
