Mazzarello P
Istituto di Genetica Biochimica, ed Evoluzionistica CNR, Pavia, Italy.
J Hist Neurosci. 1999 Aug;8(2):121-31. doi: 10.1076/jhin.8.2.121.1836.
Born in Corteno, a tiny village in the province of Brescia, Camillo Golgi studied at the University of Pavia where he graduated in medicine in 1865 under the guidance of the psychiatrist Cesare Lombroso who sparked his vocation to study the brain. Golgi then began to learn histological techniques under the direction of the pathologist Giulio Bizzozero. In 1872 he moved to Abbiategrasso as chief of a hospital for chronic diseases. In a rudimentary laboratory he developed the silver-bichromate staining technique, the 'black reaction', which was a breakthrough for nervous tissue structure research. While in Abbiategrasso Golgi demonstrated the branching of the axons, and observed striatal and cortical lesions in a case of chorea. He returned to Pavia as Professor of Histology and General Pathology, and made a series of important discoveries that still bear his name: the Golgi tendon organ, the Golgi-Mazzoni corpuscles, another Golgi method to stain nerve cells based on the use of potassium dichromate and mercuric chloride, the canaliculi of the parietal cells of the gastric glands (Muller-Golgi tubules), the Golgi-Rezzonico myelin's annular apparatus (or Golgi-Rezzonico horny funnels), the cycle of malarian parasites (Golgi cycle), the relationship between recurrent malarian fever bouts and the multiplication of the Plasmodium in the blood (Golgi law), the relationship between the vascular pole of the Malpighian glomerulus and the distal tubule, the Golgi's pericellular nets and finally, and most importantly, the cytoplasmic 'internal reticular apparatus' (Golgi apparatus). In 1906 Golgi was awarded the Nobel prize for Medicine or Physiology. He died in Pavia on 21 January 1921.
卡米洛·高尔基出生于布雷西亚省的一个小村庄科尔泰诺,他在帕维亚大学学习,并于1865年在精神病学家切萨雷·龙勃罗梭的指导下毕业于医学专业,龙勃罗梭激发了他研究大脑的热情。随后,高尔基在病理学家朱利奥·比佐泽罗的指导下开始学习组织学技术。1872年,他前往阿比亚泰格拉索,担任一家慢性病医院的院长。在一个简陋的实验室里,他开发了重铬酸银染色技术,即“黑色反应”,这是神经组织结构研究的一项突破。在阿比亚泰格拉索期间,高尔基展示了轴突的分支,并在一例舞蹈病中观察到纹状体和皮质病变。他回到帕维亚,担任组织学和普通病理学教授,并做出了一系列至今仍以他的名字命名的重要发现:高尔基腱器官、高尔基-马佐尼小体、另一种基于重铬酸钾和氯化汞使用的神经细胞染色高尔基方法、胃腺壁细胞的小管(米勒-高尔基小管)、高尔基-雷佐尼科髓磷脂的环形装置(或高尔基-雷佐尼科角质漏斗)、疟原虫的周期(高尔基周期)、复发性疟疾发热发作与疟原虫在血液中繁殖的关系(高尔基定律)、马尔皮基氏肾小球的血管极与远端小管的关系、高尔基的细胞周围网,最后也是最重要的,细胞质“内部网状结构”(高尔基体)。1906年,高尔基被授予诺贝尔医学奖或生理学奖。他于1921年1月21日在帕维亚去世。