Ghosh Sanjib Kumar
Department of Anatomy, All India Institute of Medical Sciences, Phulwarisharif, Patna, India.
Anat Cell Biol. 2020 Dec 31;53(4):385-392. doi: 10.5115/acb.20.196.
Camillo Golgi was an extraordinary scientist whose contributions in the domain of neuroanatomy proved to be critical for emergence of neuroscience as a sovereign scientific discipline. Golgi's invention of the () was a watershed event as it allowed remarkable visualization of the organizational pattern of elements of nervous system among complex puzzle of close knit interconnections. Till this time thin filamentary extensions of neural cells (axon and dendrites) could not be visualized with available staining techniques because of their slender and transparent nature. However invention of and its subsequent application demystified the basic architecture of brain tissue which was now visible to the scholars in all its complexity in microscopic studies. Golgi is also credited with the discovery of two types of sensory receptors in muscle tendons: Golgi tendon organ and Golgi-Mazzoni corpuscles. Golgi was the first to be successful in staining myelin component of axon, which he used to discover the myelin annular apparatus. He identified the complete life cycle of Plasmodium (malarial parasite) in human erythrocytes. His research on histological details of human kidney highlighted the existence of juxtaglomerular apparatus. Later on Spanish scientist Santiago Ramón y Cajal, based on the use of Golgi's Staining (Black Reaction) documented the morphologic details of nervous system in a more refined manner, which eventually led to the emergence of . In recognition of their exemplary contributions in neuroscience Golgi and Cajal were jointly awarded the Nobel Prize for Physiology or Medicine in 1906.
卡米洛·高尔基是一位杰出的科学家,他在神经解剖学领域的贡献被证明对神经科学作为一门独立的科学学科的兴起至关重要。高尔基发明的()是一个分水岭事件,因为它使人们能够在紧密相连的复杂网络难题中,对神经系统元素的组织模式进行显著的可视化。在此之前,由于神经细胞的细丝状延伸部分(轴突和树突)细长且透明,现有的染色技术无法将其可视化。然而,()的发明及其后续应用揭开了脑组织基本结构的神秘面纱,学者们现在可以在显微镜研究中看到其所有的复杂性。高尔基还因在肌肉肌腱中发现两种类型的感觉受体而受到赞誉:高尔基腱器官和高尔基 - 马佐尼小体。高尔基是第一个成功染色轴突髓鞘成分的人,他用此发现了髓鞘环装置。他确定了疟原虫在人类红细胞中的完整生命周期。他对人类肾脏组织学细节的研究突出了球旁器的存在。后来,西班牙科学家圣地亚哥·拉蒙·伊·卡哈尔基于高尔基染色法(黑色反应),更精细地记录了神经系统的形态学细节,这最终导致了()的出现。为了表彰他们在神经科学方面的杰出贡献,高尔基和卡哈尔于1906年共同获得诺贝尔生理学或医学奖。