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卡米洛·高尔基与高尔基体的发现

Camillo Golgi and the discovery of the Golgi apparatus.

作者信息

Dröscher A

机构信息

Institut für die Geschichte der Naturwissenschaften, Mathematik und Technik, Universität Hamburg, Germany.

出版信息

Histochem Cell Biol. 1998 May-Jun;109(5-6):425-30. doi: 10.1007/s004180050245.

Abstract

Camillo Golgi (1843-1926) was born at Corteno, near Brescia, in northern Italy. After graduating in Medicine at the ancient University of Pavia, the former seat of great scientists and naturalists, Golgi continued a long-standing Italian tradition by studying the histology of the nervous system. While working as a modest physician at Abbiategrasso, a small town near Pavia, he developed a silver-osmium technique, the "reazione nera" (black reaction), for which he was awarded the Nobel Prize in 1906. In the late 1890's, 25 years after the publication of his black reaction and while Professor of General Pathology in Pavia, Golgi noticed a fine internal network in only partially silver-osmium-blackened Purkinje cells. Following confirmation by his assistant Emilio Veratti, Golgi published the discovery, called the "apparato reticolare interno", in the Bollettino della Società medico-chirurgica di Pavia in 1898, which is now considered the birthday of the "Golgi apparatus". The discovery of the Golgi apparatus can be added to the long list of accidental discoveries. The man after whom it is named was not a cytologist engaged in studying the inner structure of the cell, but a pathologist searching to prove a neuroanatomical theory.

摘要

卡米洛·高尔基(1843 - 1926)出生于意大利北部布雷西亚附近的科尔泰诺。在古老的帕维亚大学医学院毕业后,高尔基延续了意大利悠久的传统,研究神经系统的组织学。帕维亚大学曾是伟大科学家和博物学家的摇篮。在帕维亚附近的小镇阿比亚泰格拉索担任普通医生期间,他发明了一种银锇技术,即“黑色反应”,并因此在1906年获得诺贝尔奖。19世纪90年代后期,在他发表黑色反应25年后,当时他是帕维亚大学的普通病理学教授,他注意到在仅部分被银锇染黑的浦肯野细胞中有一个精细的内部网络。在他的助手埃米利奥·韦拉蒂证实后,高基于1898年在《帕维亚医学 - 外科学会公报》上发表了这一发现,称之为“内网器”,现在这一天被视为“高尔基体”的诞辰。高尔基体的发现可以加入到一长串偶然发现的名单中。以他名字命名的这个细胞器的发现者并非从事细胞内部结构研究的细胞学家,而是一位试图证明一种神经解剖学理论的病理学家。

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