Lafont O
Faculté de médecine et pharmacie de Rouen, Saint-Etienne-de-Rouvray cedex.
Rev Hist Pharm (Paris). 1996;43(310):269-73.
Charles Frédéric Gerhardt (1816-1856) mentioned in his Traité de chimie Organique (1854) a publication, in French (realized in 1852 but published in 1853) entitled "Researches on anhydrous organic acids" in which, was reported the reaction of sodium salicylate with acetyl chloride. He thought that the reaction product was an acid anhydride, but obtained really crude acetylsalicylic acid. Later on, but also in 1853, a publication in german, by the same author related the same experiments. Surprisingly only the second publication has been mentioned in most of the historical studies on the subject. Acetyl salicylic acid was identified and synthesised in 1859 by von Gilm by another method and the product obtained by Gerhardt was identified to it in 1869.
查尔斯·弗雷德里克·热拉尔（1816 - 1856）在其《有机化学论著》（1854年）中提及了一篇用法语撰写的出版物（于1852年完成但1853年出版），题为《关于无水有机酸的研究》，其中报道了水杨酸钠与乙酰氯的反应。他认为反应产物是一种酸酐，但实际上得到的是粗制的乙酰水杨酸。后来，同样在1853年，这位作者用德语发表了相关的相同实验。令人惊讶的是，在关于该主题的大多数历史研究中，只提到了第二篇出版物。1859年冯·吉尔姆用另一种方法鉴定并合成了乙酰水杨酸，1869年将热拉尔得到的产物鉴定为乙酰水杨酸。
