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右旋苯丙胺、马普替林、左旋多巴和氟哌啶醇对雪貂(Putorius furo L.)捕食行为各组成部分的影响

Effects of d-amphetamine, maprotiline, L-dopa, and haloperidol on the components of the predatory behavior of the ferret, Putorius furo L.

作者信息

Schmidt W J

出版信息

Psychopharmacology (Berl). 1979 Sep;64(3):355-9. doi: 10.1007/BF00427524.

Abstract

Ferret predation on rats was examined in an arena. One hour before the test one of the following drugs was administered. d-Amphetamine (0.8 and 1.4 mg/kg IM), MAPROTILINE (10 AND 40 Mg/kg orally), L-dopa (30 and 60 mg/kg orally), or haloperidol (0.14 and 0.6 mg/kg IM). Provided that capture was successful, the sequence of the behavioral components was not changed by these drugs. With the exceptions of paw movements and rolling over, which were not affected by the drugs, the components of predatory behavior were influenced differently. This leads to the assumption that a drug affects different mechanisms which control behavior. It is assumed that dopamine is involved in the control of capture elicitation as well as in the control of pursuit and biting. Capture elicitation was inhibited by d-amphetamine and L-dopa, but not by maprotiline, and was even facilitated by haloperidol. The orientation of pursuit movements and biting was impaired by L-dopa and improved by haloperidol, whereas maprotiline did not influence these components.

摘要

在一个场地中研究了雪貂对大鼠的捕食行为。在测试前一小时,给予以下药物之一:右旋苯丙胺(0.8和1.4毫克/千克,肌肉注射)、马普替林(10和40毫克/千克,口服)、左旋多巴(30和60毫克/千克,口服)或氟哌啶醇(0.14和0.6毫克/千克,肌肉注射)。如果捕食成功,这些药物不会改变行为成分的顺序。除了爪子运动和翻滚不受药物影响外,捕食行为的其他成分受到的影响各不相同。这导致人们推测一种药物会影响控制行为的不同机制。据推测,多巴胺参与了捕食引发的控制以及追逐和撕咬的控制。捕食引发受到右旋苯丙胺和左旋多巴的抑制,但不受马普替林的抑制,甚至氟哌啶醇还会促进捕食引发。左旋多巴会损害追逐动作和撕咬的方向,而氟哌啶醇则会改善这些,而马普替林不会影响这些成分。

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