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[颅脑损伤患者自身免疫反应的临床诊断意义]

[Clinico-diagnostic significance of autoimmune reactions in patients with cranio-cerebral injury].

作者信息

Livshits L Ia, Shakarova G G

出版信息

Vopr Neirokhir. 1975 Jul-Aug(4):33-7.

PMID:1162940
Abstract

A trauma of the brain has been found to be regularly attended by the development of anticerebral antibodies. The frequency with which the anticerebral autoantibodies circulating in the blood stream are detected and their titre depend upon the extent to which the brain matter has been damaged. Positive reactions with the cerebral antigen become apparent habitually by the end of the 1st post-traumatic week and continue to be present in the majority of patients till their discharge from the hospital and in cases of more severe injuries-even for a much longer time. Earlier and more distinct formation of anticerebral antibodies found in patients with a repeated cerebro-cranial injury bears evidence to sensitization of the organism with the cerebral tissue antigens.

摘要

人们发现,脑部创伤常常伴随着抗脑抗体的产生。血液中循环的抗脑自身抗体的检测频率及其滴度取决于脑实质的受损程度。创伤后第一周末,通常会出现与脑抗原的阳性反应,并且在大多数患者出院前该反应一直存在,在伤势较重的情况下,甚至会持续更长时间。在反复发生颅脑损伤的患者中发现抗脑抗体形成得更早、更明显,这证明机体对脑组织抗原产生了致敏作用。

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