Lehmann A G, Busnel R G
Psychopharmacology (Berl). 1979 Sep;65(1):79-84. doi: 10.1007/BF00491983.
The effects of noise, alcohol, and the combination of the two were studied on muscular fatigue in several mouse strains to investigate a possible interaction between the two stresses. Muscular fatigue was measured by latency to submersion during a forced-swimming test. Animals were exposed to acoustic stimuli of fixed frequency and intensity for 2h preceding the test. Ethanol was administered orally from 30 min to 3h 30 min prior to testing. Alcohol doses and sound intensities were subliminal when administered separately. While no significant interaction occurred between alcohol and audible sound, the interaction between alcohol and infrasound was highly significant indicating that their joint effects are more than merely additive. Blood alcohol measurements indicate that these interactive effects are prolonged for more than 2h after elimination of alcohol from the blood. Effects are similar in genetically deaf and hearing mice, implicating involvement of nonauditory pathways.
研究了噪声、酒精以及二者组合对几种小鼠品系肌肉疲劳的影响，以探究这两种应激源之间可能存在的相互作用。通过强迫游泳试验中浸没潜伏期来测量肌肉疲劳。在试验前2小时，让动物暴露于固定频率和强度的声学刺激下。在测试前30分钟至3小时30分钟口服乙醇。单独给予酒精剂量和声音强度时均为阈下刺激。虽然酒精和可听声之间未发生显著相互作用，但酒精和次声之间的相互作用非常显著，表明它们的联合效应不仅仅是简单的相加。血液酒精测量表明，从血液中消除酒精后，这些相互作用效应会持续超过2小时。在遗传性耳聋小鼠和听力正常小鼠中效应相似，这表明非听觉通路也参与其中。
