Busnel R G, Lehmann A G
Behav Brain Res. 1980 Aug;1(4):351-6. doi: 10.1016/0166-4328(80)90028-5.
Swimming behavior in the mouse was used to study the motor disturbances induced by alcohol, and the effects of vitamin C upon these disturbances were assessed. High doses of vitamin C (125 and 500 mg/kg) prevented any swimming impairment due to ethanol; however, lower doses of vitamin C (62.5 mg/kg) had no significant effect. When given 1 h before alcohol, the protective effect of vitamin C was reduced. The alcohol-induced intoxication lasted beyond alcohol's elimination from the blood, suggesting that the intoxication is maintained by a metabolite of ethanol or by an effect of ethanol, or a metabolite, on another metabolic system.
利用小鼠的游泳行为来研究酒精引起的运动障碍，并评估维生素C对这些障碍的影响。高剂量的维生素C（125和500毫克/千克）可预防因乙醇导致的任何游泳能力受损；然而，低剂量的维生素C（62.5毫克/千克）没有显著效果。在饮酒前1小时给予维生素C，其保护作用会降低。酒精引起的中毒在血液中的酒精消除后仍持续存在，这表明中毒是由乙醇的代谢产物维持的，或者是由乙醇或其代谢产物对另一个代谢系统的作用所维持的。
