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旋毛虫感染对劳氏白血病发展的影响

[Effect of Trichinella spiralis infection on the development of Rauscher leukemia].

作者信息

Trubcheninova L P, Chimishkian K L, Ovutian G Sh, Babichev V A, Svet-Moldavskiĭ G Ia

出版信息

Vopr Virusol. 1975 May-Jun(3):344-8.

PMID:1162955
Abstract

The influence of Trichinella spiralis on the course of Rausher leukemia in mice was studied. Inoculation of mice with Trichinella spiralis larvae 15, 16 and 30 days before infection with Rausher leukemia virus was shown to stimulate splenomegaly, whereas preinoculation of Rausher leukemia virus at 6, 12 and 18 days before infection with Trichinella spiralis resulted in inhibition of splenomegaly. Under the experimental conditions used, no effect of T. spiralis on reproduction of Rausher leukemia virus was observed, as virus titers in the plasm of mice with marked stimulation or inhibition of splenomegaly were identical and did not differ from those in mice without Trichinella spiralis invasion.

摘要

研究了旋毛虫对小鼠劳斯氏白血病病程的影响。结果表明,在感染劳斯氏白血病病毒前15、16和30天给小鼠接种旋毛虫幼虫可刺激脾肿大,而在感染旋毛虫前6、12和18天预先接种劳斯氏白血病病毒则会抑制脾肿大。在所采用的实验条件下,未观察到旋毛虫对劳斯氏白血病病毒繁殖有影响,因为脾肿大受到显著刺激或抑制的小鼠血浆中的病毒滴度相同,且与未受旋毛虫感染的小鼠无异。

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