Overgaard K, Overgaard J
Acta Radiol Ther Phys Biol. 1975 Apr;14(2):164-76. doi: 10.3109/02841867509132658.
In mouse experiments a high curative effect on implanted tumours was obtained by successive application of low local heat and roentgen doses. Histologic and histochemical examinations of tumours so treated revealed a special reaction in the tissues. A total and rapid destruction of all hypoxic tumour tissue was observed and (in successful cases) a total blockade of all mitotic activity in euoxic tumour tissue was followed by a long-drawn necrobiotic decay of the existent tumour cells. The disturbances are electively bound to the tumour cells, only some normal tissues may secondarily be injured. A rapid and intensive lysosomal activity in all the tumour cells may probably be of importance in the reaction.
在小鼠实验中，通过连续施加低剂量局部热和X射线剂量，对植入肿瘤取得了很高的疗效。对如此处理过的肿瘤进行组织学和组织化学检查，发现组织中有特殊反应。观察到所有缺氧肿瘤组织完全且迅速地被破坏，并且（在成功的病例中），正常氧合肿瘤组织中的所有有丝分裂活动完全被阻断，随后现存肿瘤细胞出现长时间的渐进性坏死衰变。这些干扰选择性地作用于肿瘤细胞，只有一些正常组织可能会受到继发性损伤。所有肿瘤细胞中快速且强烈的溶酶体活性可能在该反应中起重要作用。
