Dobrin R S, Vernier R L, Fish A L
Am J Med. 1975 Sep;59(3):325-33. doi: 10.1016/0002-9343(75)90390-3.
We describe two patients with a unique granulomatous syndrome who presented with renal failure secondary to diffuse eosinophilic interstitial nephritis. Both had bilateral anterior uveitis, bone marrow granulomas, hypergammaglobulinemia and an increased sedimentation rate. One patient had lymph node granulomas and an immunoglobulin G (IgG) rheumatoid factor. An extensive investigation for an etiologic agent was unrewarding, and neither patient could be placed into any existing diagnostic category. Over a period of 2 years both patients have experienced improved renal function and dissolution of their bone marrow granulomas.
我们描述了两名患有独特肉芽肿综合征的患者，他们因弥漫性嗜酸性间质性肾炎继发肾衰竭。两人均患有双侧前葡萄膜炎、骨髓肉芽肿、高球蛋白血症和血沉加快。其中一名患者有淋巴结肉芽肿和免疫球蛋白G（IgG）类风湿因子。对病原体进行的广泛调查没有结果，两名患者均无法归入任何现有的诊断类别。在两年的时间里，两名患者的肾功能均有所改善，骨髓肉芽肿也消失了。
