Mongalo Milliejoan, Diaz Victoria, Kim Andrew, Hou Jean, Bourji Khalil
Internal Medicine, Health Corporation of America (HCA) MountainView Hospital, Las Vegas, USA.
Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA.
Cureus. 2024 Aug 5;16(8):e66202. doi: 10.7759/cureus.66202. eCollection 2024 Aug.
Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uncommon autoimmune disorder that is defined by tubulointerstitial nephritis and uveitis. It is frequently underdiagnosed or goes unrecognized due to the challenges of accurately diagnosing the syndrome. TINU has mostly been seen among female pediatric patients with primarily bilateral anterior uveitis. However, screening for kidney disease often is overlooked; therefore, it is important for ophthalmologists, nephrologists, and rheumatologists to routinely screen for kidney disease and have TINU as a differential. We present a case of an adult female who had bilateral anterior uveitis for several years and then was found to have advanced chronic kidney disease, showing tubulointerstitial nephritis (TIN) features on renal biopsy.
肾小管间质性肾炎和葡萄膜炎(TINU)综合征是一种罕见的自身免疫性疾病,其定义为肾小管间质性肾炎和葡萄膜炎。由于准确诊断该综合征存在挑战,它常常被漏诊或未被识别。TINU主要见于患有双侧前部葡萄膜炎的儿科女性患者。然而,肾脏疾病的筛查常常被忽视;因此,眼科医生、肾病学家和风湿病学家常规筛查肾脏疾病并将TINU作为鉴别诊断很重要。我们报告一例成年女性病例,该患者患有双侧前部葡萄膜炎数年,随后被发现患有晚期慢性肾脏病,肾活检显示具有肾小管间质性肾炎(TIN)特征。