Baum J L, Barza M, Lugar J, Onigman P
Am J Ophthalmol. 1975 Sep;80(3 Pt 2):513-5. doi: 10.1016/0002-9394(75)90218-4.
We evaluated the effects of the addition of corticosteroids to antibiotic therapy in the treatment of staphylococcal endophthalmitis in rabbits. Twenty-four hours after the induction of infection with Staphylococcus aureus, penicillin G, penicillin G and dexamethasone or prednisolone, or saline was injected retrobulbarly for ten days. Afterward, there was no ophthalmoscopic difference between the penicillin and corticosteroid-treated group and those animals receiving only penicillin G. At day 60, however, the fundus was visible in 64% of eyes treated with penicillin G with corticosteroids in contrast to 39% of those eyes treated only with penicillin G (P less than .025). The results between dexamethasone and prednisolone use were not significant. Retrobulbar corticosteroids in combination with effective antibiotic therapy effectively treated experimental bacterial endophthalmitis.
我们评估了在兔葡萄球菌性眼内炎治疗中添加皮质类固醇至抗生素疗法的效果。在用金黄色葡萄球菌诱导感染24小时后，将青霉素G、青霉素G与地塞米松或泼尼松龙，或生理盐水球后注射10天。之后，青霉素与皮质类固醇治疗组和仅接受青霉素G的动物之间在检眼镜检查上没有差异。然而，在第60天时，与仅用青霉素G治疗的39%的眼睛相比，用青霉素G联合皮质类固醇治疗的眼睛中有64%眼底可见（P小于0.025）。地塞米松和泼尼松龙的使用结果无显著差异。球后注射皮质类固醇联合有效的抗生素疗法可有效治疗实验性细菌性眼内炎。
