Rasmussen L
Dan Medicinhist Arbog. 1998:61-76.
Louis Pasteur in France saw that microbes might cause disease, Gerhard Armauer Hansen in Norway established a connection between a bacterium and a human disease, and Robert Koch in Germany supplied the final proof that linked bacteria to disease. From then on there was an explosion in interest and techniques for cultivation of bacteria. It lasted about 30 years before Harrison in the USA succeeded in growing cells from multicellular organisms in pure culture. His technique came to Denmark at an early time point and the Rockefeller Foundation in New York and the Carlsberg Foundation in Copenhagen joined forces and built the Biological Institute of the Carlsberg Foundation in order to support Albert Fischer in his study of cell biology. His first assistant at this Institute, Fritz Lipmann, won the Nobel Prize for 1953 for work initiated there. The Institute remained a center for cell biology for almost 50 years. At the neighboring Rockefeller Institute in Copenhagen Einar Lundsgaard obtained results showing in the short perspective that current concepts of cellular utilization of energy were wrong, and in the long perspective his assistant, Herman Kalckar, would formulate modern concepts of cellular oxidative phosphorylations. This review is based in part on films from the 1930's.
法国的路易·巴斯德发现微生物可能引发疾病,挪威的格哈德·阿玛尔·汉森确立了一种细菌与人类疾病之间的联系,而德国的罗伯特·科赫提供了将细菌与疾病联系起来的最终证据。从那时起,人们对细菌培养的兴趣和技术出现了爆发式增长。大约持续了30年后,美国的哈里森成功地在纯培养中培养出多细胞生物的细胞。他的技术很早就传到了丹麦,纽约的洛克菲勒基金会和哥本哈根的嘉士伯基金会联合起来,建立了嘉士伯基金会生物研究所,以支持阿尔伯特·菲舍尔进行细胞生物学研究。他在该研究所的第一助手弗里茨·李普曼因在那里开展的工作于1953年获得诺贝尔奖。该研究所近50年来一直是细胞生物学的中心。在哥本哈根相邻的洛克菲勒研究所,埃纳尔·伦德加德取得的结果短期内表明当时关于细胞能量利用的概念是错误的,从长远来看,他的助手赫尔曼·卡尔卡将阐述细胞氧化磷酸化的现代概念。这篇综述部分基于20世纪30年代的影片。