Lee K P, Hebert R R, Sherman H, Aftosmis J G, Waritz R S
Arch Environ Health. 1975 Sep;30(9):465-71. doi: 10.1080/00039896.1975.10666752.
Single oral administration of octabromobiphenyls at 1,000 mg/kg, or two consecutive doses of 3,000 mg/kg, to rats produced liver enlargement. Light microscopic examination revealed hepatocellular hyperplasia, margination of basophillic cytoplasm, and foamy cytoplasmic alteration on the third day posttreatment. Laminated cytoplasmic inclusions developed seven days after treatment and subsequently disappeared about one week later. Under electron microscopy, the cytoplasmic margination corresponded to peripherally displaced granular reticulum and the foamy cytoplasm was recognizable as proliferating agranular reticulum with depletion of particualte glycogen. The cytoplasmic inclusions were identified as myelin configurations enclosing lipid bodies, membrane-bound vacuoles with whorled figures, and vesicular agranular reticulum. In the early developmental stages, the myelin figures were studded with ribosomes and associated with the granular reticulum.
给大鼠单次口服1000毫克/千克的八溴联苯，或连续两次给予3000毫克/千克的剂量，会导致肝脏肿大。光学显微镜检查显示，在治疗后第三天出现肝细胞增生、嗜碱性细胞质边缘化以及泡沫状细胞质改变。层状细胞质内含物在治疗七天后出现，随后在大约一周后消失。在电子显微镜下，细胞质边缘化对应于颗粒状内质网向周边移位，而泡沫状细胞质可识别为无颗粒内质网增生且颗粒状糖原减少。细胞质内含物被鉴定为包裹脂质体的髓鞘结构、具有涡状图形的膜结合空泡以及泡状无颗粒内质网。在发育早期阶段，髓鞘样结构上布满核糖体并与颗粒状内质网相关联。
