长期摄入多溴联苯后小鼠肝细胞中核内脂质包涵体的存在。
The presence of intranuclear lipid inclusions in hepatocytes of mice after chronic ingestion of polybrominated biphenyl.
作者信息
Martino L J, Wilson-Martino N A, Benitz K F
出版信息
Arch Toxicol. 1981 Apr;47(2):155-8. doi: 10.1007/BF00332357.
PMID:6268014
Abstract
Electron microscopic study of livers from mice fed 167 ppm polybrominated biphenyl (PBB) for 12 weeks showed hepatocytes with nuclei containing varied amounts of lipid inclusions. The inclusions appeared as spherical vacuoles free in the nuclear matrix. This is the first report of the induction of lipid inclusions within the nucleus by a halogenated hydrocarbon.
摘要
对喂食167 ppm多溴联苯（PBB）12周的小鼠肝脏进行的电子显微镜研究显示，肝细胞的细胞核中含有不同数量的脂质包涵体。这些包涵体表现为游离于核基质中的球形空泡。这是关于卤代烃诱导细胞核内脂质包涵体的首次报道。
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