Anderson H A, Holstein E C, Daum S M, Sarkozi L, Selikoff I J
Environ Health Perspect. 1978 Apr;23:333-9. doi: 10.1289/ehp.7823333.
Serum activity of SGOT, SGPT, LDH, and alkaline phosphatase was measured in 614 Michigan adults exposed to PBB and 141 Wisconsin adults not so exposed. The Michigan group had higher prevalence of abnormal SGOT (p less than 0.005) and SGPT (p less than 0.005). A clear sex difference was observed. Michigan men had a higher prevalence of abnormal SGPT (p less than 0.005) and LDH (p less than 0.005) than Michigan women, and a higher prevalence than Wisconsin men of abnormal SGOT (p less than 0.005) and SGPT (p less than 0.01). These differences could not be ascribed to differing patterns of alcohol consumption, laboratory error, or choice of criteria for normality/abnormality. Seven Michigan subgroups were defined on the basis of the criteria by which they had been selected to participate. The two subgroups who were essentially self-invited did not differ from the remaining five randomly selected subgroups combined in prevalence of these abnormal liver function tests. Based on 364 serum PBB analyses thus far analyzed of the 614 Michigan participants, no obvious relationship between serum PBB values and liver function tests was observed. However, this is a tentative conclusion that will be further evaluated when remaining serum PBB analyses are completed. The greater prevalence of abnormal SGPT and SGOT among Michigan dairy farm residents compared to the Wisconsin dairy farm residents is tentatively ascribed to the former group's exposure to PBB.
对614名接触多溴联苯的密歇根州成年人和141名未接触多溴联苯的威斯康星州成年人进行了血清谷草转氨酶（SGOT）、谷丙转氨酶（SGPT）、乳酸脱氢酶（LDH）和碱性磷酸酶活性的检测。密歇根州的人群中SGOT异常（p<0.005）和SGPT异常（p<0.005）的患病率更高。观察到明显的性别差异。密歇根州男性的SGPT异常（p<0.005）和LDH异常（p<0.005）患病率高于密歇根州女性，且SGOT异常（p<0.005）和SGPT异常（p<0.01）的患病率高于威斯康星州男性。这些差异不能归因于饮酒模式不同、实验室误差或正常/异常标准的选择。根据入选标准将614名密歇根州参与者分为七个亚组。两个基本为自邀参与的亚组在这些肝功能异常检测的患病率方面与其余五个随机选择的亚组合并后没有差异。基于对614名密歇根州参与者中迄今分析的364份血清多溴联苯分析，未观察到血清多溴联苯值与肝功能检测之间有明显关系。然而，这是一个初步结论，在完成其余血清多溴联苯分析后将进一步评估。与威斯康星州奶农相比，密歇根州奶农中SGPT和SGOT异常的患病率更高，初步归因于前者接触了多溴联苯。
