Byrd C L, Yahr W Z, Greenberg J J
Ann Thorac Surg. 1975 Sep;20(3):265-73. doi: 10.1016/s0003-4975(10)64218-x.
During the past two years 8 patients were seen with thrombosis of their Bjork-Shiley aortic valves. Six patients were from our series, an incidence of 4% and 2 patients had their original valve implanted at another institution. All patients had substantial problems with anticoagulation therapy. Three died prior to operation. Early detection and emergency surgical intervention is mandatory for survival. At operation debridement of all thrombotic material from the valve provided satisfactory immediate hemodynamic improvements as well as freedom from complications for up to two years. Therapeutic levels of anticoagulation with warfarin are the only apparent protection from thrombosis of the Bjork-Shiley aortic valve.
在过去两年中，我们诊治了8例Bjork-Shiley主动脉瓣血栓形成的患者。其中6例来自我们的病例系列，发病率为4%，另外2例患者最初的瓣膜是在其他机构植入的。所有患者在抗凝治疗方面都存在严重问题。3例患者在手术前死亡。为了挽救生命，必须进行早期检测和紧急手术干预。手术时清除瓣膜上所有的血栓物质，可立即带来令人满意的血流动力学改善，并且在长达两年的时间内无并发症发生。华法林的治疗性抗凝水平是预防Bjork-Shiley主动脉瓣血栓形成的唯一明显措施。
