Olney H J, Le Beau M M
Section of Hematology/Oncology, University of Chicago, 5841 S. Maryland, MC 2115, Chicago, Illinois 60637, USA.
Best Pract Res Clin Haematol. 2001 Sep;14(3):479-95. doi: 10.1053/beha.2001.0151.
The myelodysplastic syndromes are a collection of five clinico-pathological entities with a wide spectrum of clinical behaviours and survival outcomes. Cytogenetic analysis has been instrumental in refining the prognosis, predicting the likelihood of progression to acute myeloid leukaemia and median survival, and in establishing clonality of these diseases. This review highlights the most frequent abnormalities and summarizes their clinical and genetic features.
骨髓增生异常综合征是一组包含五个临床病理实体的疾病，具有广泛的临床行为和生存结局。细胞遗传学分析有助于完善预后评估、预测进展为急性髓系白血病的可能性及中位生存期，并有助于确定这些疾病的克隆性。本综述重点介绍了最常见的异常情况，并总结了它们的临床和遗传学特征。
