Kleinrok Z, Przegaliński E
Arch Immunol Ther Exp (Warsz). 1975;23(4):497-503.
The influence of cholinomimetics (carbachol--CCh, physostigmine--Pht, pilocarpine--Pil) and cholinolytics (atropine--At, scopolamine--Sc) injected into the lateral ventricle of the brain (ivtr) in rats on metabolism of 5-HT was studied by assaying levels of 5-HT and 5-HIAA. In several comparative experiments cholinomimetics were injected i.p. CCh had no influence on levels of 5-HT and 5-HIAA when injected i.p., but raised levels of 5-HIAA injected ivtr. Pht had no influence on concentrations of both substances by either route of administration. Pil raised levels of 5-HIAA when injected i.p. (and by this route of administration also raised levels of 5-HT) as well as ivtr, Both cholinolytics injected ivtr had no influence on concentrations of 5-HT or 5-HIAA.
通过测定5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）的水平，研究了向大鼠脑侧脑室注射拟胆碱药（卡巴胆碱——CCh、毒扁豆碱——Pht、毛果芸香碱——Pil）和解胆碱药（阿托品——At、东莨菪碱——Sc）对5-羟色胺代谢的影响。在几个对比实验中，拟胆碱药通过腹腔注射给药。腹腔注射CCh对5-HT和5-HIAA的水平没有影响，但脑侧脑室注射时会提高5-HIAA的水平。无论通过哪种给药途径，Pht对这两种物质的浓度都没有影响。腹腔注射Pil（通过这种给药途径也会提高5-HT的水平）以及脑侧脑室注射时都会提高5-HIAA的水平。两种解胆碱药脑侧脑室注射时对5-HT或5-HIAA的浓度均无影响。
