Zhila V A, Gatsenko G N, Gromov L A
Farmakol Toksikol. 1991 Nov-Dec;54(6):14-6.
The experiments on albino rats with the use of the radioimmunoassay showed that M-cholinoblockers (atropine, amizil, glypine) decrease the contents of enkephalins and beta-endorphin in the brain and blood whereas M-cholinomimetics (arecoline, nicotine, physostigmine) increase the level of opioid neuropeptides. This suggested that between cholinoblockers and cholinomimetics there is not only functional but also biochemical antagonism at the level of the opiate system. In addition, the statement is developed that toxic effects of cholinoblockers and cholinomimetics are largely related to disturbances of metabolism and function of opioid neuropeptides.
对白化大鼠进行的使用放射免疫测定法的实验表明，M胆碱受体阻断剂（阿托品、阿米齐尔、格利平）会降低大脑和血液中脑啡肽和β-内啡肽的含量，而M胆碱受体激动剂（槟榔碱、尼古丁、毒扁豆碱）会提高阿片类神经肽的水平。这表明胆碱受体阻断剂和胆碱受体激动剂之间不仅在功能上，而且在阿片系统水平上存在生化拮抗作用。此外，还提出胆碱受体阻断剂和胆碱受体激动剂的毒性作用在很大程度上与阿片类神经肽的代谢和功能紊乱有关。
