尿癌胚抗原（CEA）样分子与尿路上皮恶性肿瘤：一项临床评估
Urinary carcinoembryonic antigen (CEA)-like molecules and urothelial malignancy: a clinical appraisal.
作者信息
Coombers G B, Hall R R, Laurence J R, Neville A M
出版信息
Br J Cancer. 1975 Feb;31(2):135-42. doi: 10.1038/bjc.1975.18.
Abstract
A total of 190 patients being treated or followed up for urothelial carcinoma have been studied by the serial estimation of their urinary and plasma CEA levels. Only 46% of patients with a urothelial neoplasm present have a raised urinary CEA level. Infection or ileal conduit urine vitiate the result as they produce high CEA levels in the urine in the absence of any neoplastic disease. The accuracy of urinary CEA estimations is compared with that of cytology. Plasma CEA levels do not serve as a useful guide to the presence of extra-urinary tract tumour spread if taken as isolated readings. However, serial plasma CEA estimations may indicate that metastatic disease is present several months before its detection by the more usual clinical methods in a minority of patients.
摘要
通过对190例接受尿路上皮癌治疗或随访的患者进行尿液和血浆癌胚抗原（CEA）水平的系列评估，对其进行了研究。在患有尿路上皮肿瘤的患者中，只有46%的患者尿液CEA水平升高。感染或回肠造口尿液会使结果无效，因为它们在没有任何肿瘤疾病的情况下会使尿液中的CEA水平升高。将尿液CEA评估的准确性与细胞学的准确性进行了比较。如果将血浆CEA水平作为单独读数，它并不能作为判断尿路外肿瘤扩散情况的有用指标。然而，在少数患者中，系列血浆CEA评估可能表明在通过更常规的临床方法检测到转移疾病前几个月就已存在转移疾病。
相似文献
1
Urinary carcinoembryonic antigen (CEA)-like molecules and urothelial malignancy: a clinical appraisal.尿癌胚抗原（CEA）样分子与尿路上皮恶性肿瘤：一项临床评估
Br J Cancer. 1975 Feb;31(2):135-42. doi: 10.1038/bjc.1975.18.
2
Urinary carcinoembryogenic antigen (CEA) in the diagnosis and follow-up of bladder carcinoma.
Br J Urol. 1983 Oct;55(5):501-7. doi: 10.1111/j.1464-410x.1983.tb03357.x.
3
[Plasma and urinary CEA-assay in patients with urological tumours (author's transl)].
Urologe A. 1976 Nov;15(6):300-3.
4
The clinical diagnostic value of the carcinoembryonic antigen (CEA) in haematuria.癌胚抗原（CEA）在血尿中的临床诊断价值。
Br J Urol. 1977 Feb;49(1):61-6. doi: 10.1111/j.1464-410x.1977.tb04525.x.
5
The clinical value of plasma and urinary carcinoembryonic antigen (CEA) assays in patients with haematuria and urothelial carcinoma.血浆和尿癌胚抗原（CEA）检测在血尿和尿路上皮癌患者中的临床价值
Eur Urol. 1980;6(6):344-6. doi: 10.1159/000473369.
6
Urine carcinoembryonic antigen determination in urinary bladder bilharziasis predicts carcinoma in patients with premalignant lesions: observation of 43 cases in Egypt.
Tanzan Health Res Bull. 2006 Sep;8(3):122-7. doi: 10.4314/thrb.v8i3.45108.
7
Clinical evaluation of urinary and serum carcinoembryonic antigen in bladder cancer.膀胱癌患者尿液和血清中癌胚抗原的临床评估
J Urol. 1975 Aug;114(2):226-9. doi: 10.1016/s0022-5347(17)66992-1.
8
Carcinoembryonic antigen and urothelial carcinoma.癌胚抗原与尿路上皮癌
Br J Urol. 1973 Feb;45(1):88-92.
9
Carcinoembryonic antigen and bladder carcinoma.癌胚抗原与膀胱癌
J Urol. 1976 Jan;115(1):46-8. doi: 10.1016/s0022-5347(17)59061-8.
10
Carcinoembryonic-like antigen in the urine of patients with carcinoma of the bladder and normal controls.膀胱癌患者及正常对照者尿液中的癌胚样抗原。
J Surg Oncol. 1974;6(2):127-31. doi: 10.1002/jso.2930060207.
引用本文的文献
1
Trends in urine biomarker discovery for urothelial bladder cancer: DNA, RNA, or protein?尿路上皮膀胱癌尿液生物标志物发现的趋势：DNA、RNA还是蛋白质？
Transl Androl Urol. 2021 Jun;10(6):2787-2808. doi: 10.21037/tau-20-1327.
2
Urine carcinoembryonic antigen levels are more useful than serum levels for early detection of Bilharzial and non-Bilharzial urinary bladder carcinoma: observations of 43 Egyptian cases.尿癌胚抗原水平在早期检测埃及血吸虫性和非埃及血吸虫性膀胱癌方面比血清水平更有用：43例埃及病例的观察结果
World J Surg Oncol. 2007 Jan 15;5:4. doi: 10.1186/1477-7819-5-4.
3
Immunohistochemical demonstration of tumor-associated antigens with the aid of monoclonal and polyclonal antisera in carcinoma of the bladder.
Urol Res. 1985;13(2):55-9. doi: 10.1007/BF00261566.
4
Carcinoembryonic antigen in serum, urine and cells of patients with bladder carcinoma.膀胱癌患者血清、尿液及细胞中的癌胚抗原
Urol Res. 1978;6(4):221-4. doi: 10.1007/BF00262622.
5
Immunoperoxidase staining of carcinoembryonic antigen in urinary bladder cancer.膀胱癌中癌胚抗原的免疫过氧化物酶染色
Urol Res. 1978;6(4):211-4. doi: 10.1007/BF00262620.
6
Isolation of CEA-like material from urinary bladder carcinoma.从膀胱癌中分离出癌胚抗原样物质。
Urol Res. 1978;6(4):215-9. doi: 10.1007/BF00262621.
7
Human tumour-associated and tumour-specific antigens: some concepts in relation to clinical oncology.人类肿瘤相关抗原和肿瘤特异性抗原：与临床肿瘤学相关的一些概念
J Clin Pathol Suppl (Assoc Clin Pathol). 1975;6:102-12. doi: 10.1136/jcp.s1-6.1.102.
本文引用的文献
1
DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.通过免疫耐受和吸收技术证明人类结肠癌中的肿瘤特异性抗原
J Exp Med. 1965 Mar 1;121(3):439-62. doi: 10.1084/jem.121.3.439.
2
Exfoliative cytology of urinary sediments; a review of 2,829 cases.尿沉渣脱落细胞学检查：2829例病例回顾
Cancer. 1958 Jan-Feb;11(1):127-37. doi: 10.1002/1097-0142(195801/02)11:1<127::aid-cncr2820110124>3.0.co;2-w.
3
The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system.人消化系统循环癌胚抗原的放射免疫测定
Proc Natl Acad Sci U S A. 1969 Sep;64(1):161-7. doi: 10.1073/pnas.64.1.161.
4
The diagnostic value of urinary cytology in patients with bladder carcinoma.尿细胞学检查对膀胱癌患者的诊断价值。
J Urol. 1971 Nov;106(5):693-6. doi: 10.1016/s0022-5347(17)61377-6.
5
Carcinoembryonic antigen in the urine of patients with urothelial carcinoma.尿路上皮癌患者尿液中的癌胚抗原。
Br Med J. 1972 Sep 9;3(5827):609-11. doi: 10.1136/bmj.3.5827.609.
6
Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma.血浆癌胚抗原在胃肠道、乳腺癌和支气管癌诊断中的作用。
Br Med J. 1972 Sep 9;3(5827):605-9. doi: 10.1136/bmj.3.5827.605.
7
Specific carcinoembryonic antigens of the human digestive system.人类消化系统的特异性癌胚抗原。
J Exp Med. 1965 Sep 1;122(3):467-81. doi: 10.1084/jem.122.3.467.
8
Studies on carcinoembryonic antigen (CEA) and a related glycoprotein, CCEA-2. Preparation and chemical characterisation.癌胚抗原（CEA）及相关糖蛋白CCEA - 2的研究。制备与化学特性分析。
Immunochemistry. 1973 Dec;10(12):841-3. doi: 10.1016/0019-2791(73)90189-4.
9
Carcinoembryonic antigen and urothelial carcinoma.癌胚抗原与尿路上皮癌
Br J Urol. 1973 Feb;45(1):88-92.
10
Carcinoembryonic antigen-like substances of human urothelial carcinomas. Isolation of components from pathological urine and comparison with colorectal carcinoma antigens.人尿路上皮癌的癌胚抗原样物质。从病理性尿液中分离成分并与结直肠癌抗原进行比较。
Biochem J. 1974 May;139(2):431-40. doi: 10.1042/bj1390431.
Zotero 插件