Godovannyĭ B A, Bol'shakova N Ia, Iushchuk N D, Stefani D V, Sidorovskiĭ Iu I
Zh Mikrobiol Epidemiol Immunobiol. 1979 Oct(10):53-6.
The work presents the data on the dynamics of accululation of the main classes of immunoglobulins (A, G and M) in coprofiltrates obtained from patients with alimentary toxicoinfections (bacteriologically confirmed salmonellosis and diseases of unknown etiology). The levels of immunoglobulins of all classes (mainly IgA and IgG) were shown to be elevated in the process of the disease. The dynamics of the increase in the level of IgA (both general and secretory) was supposed to indicate the formation of local immunity in the intestinal wall. The presence of serum IgA and the characteristic IgG dynamics seemed to be indicative of destructive processes occurring in the intestinal wall. Thus, the dynamics of accumulation of immunoglobulins in coprofiltrates obtained from patients with alimentary toxicoinfections reflects the main local pathological and immunological processes.
该研究展示了从患有食源性中毒感染（细菌学确诊为沙门氏菌病和病因不明疾病）的患者粪便滤液中获得的主要免疫球蛋白类别（A、G和M）积累动态的数据。所有类别的免疫球蛋白（主要是IgA和IgG）水平在疾病过程中均显示升高。IgA（总IgA和分泌型IgA）水平升高的动态变化被认为表明肠壁局部免疫的形成。血清IgA的存在以及特征性的IgG动态变化似乎表明肠壁正在发生破坏过程。因此，从患有食源性中毒感染的患者粪便滤液中获得的免疫球蛋白积累动态反映了主要的局部病理和免疫过程。
