Smedegård G, Revenäs B, Arfors K E
Acta Physiol Scand. 1979 Jun;106(2):191-8. doi: 10.1111/j.1748-1716.1979.tb06389.x.
Aggregate anaphylaxis was induced in eight ovalbumin-sensitized monkeys (Macaca irus). Hemodynamics, blood flow distribution and myocardial performance were studied. Following challenge, severe circulatory shock developed. Systemic arterial and left atrial pressures decreased and pulmonary arterial and right atrial pressures increased. There was a tenfold increase in pulmonary vascular resistance, and cardiac output was markedly reduced (-75%). A redistribution of the blood flow to vital organs (brain, heart and liver) occurred, at the expense of flow to other regions (muscles, kidneys, pancreas and spleen). There was also a redistribution of the blood flow within the myocardium, resulting in an unchanged right ventricular blood flow, despite a decrease in total myocardial blood flow. Right ventricular stroke work was reduced in spite of high filling pressures, whereas the decrease in left ventricular stroke work coincided with low filling pressures. It is concluded that the initial main cause of the low outflow state was an increased resistance in the pulmonary circulation followed by acute right heart failure.
在八只对卵清蛋白致敏的猕猴（食蟹猴）中诱发了全身性过敏反应。研究了血流动力学、血流分布和心肌功能。激发后，出现了严重的循环性休克。体动脉压和左心房压降低，肺动脉压和右心房压升高。肺血管阻力增加了十倍，心输出量显著降低（-75%）。血流重新分配至重要器官（脑、心脏和肝脏），其他区域（肌肉、肾脏、胰腺和脾脏）的血流减少。心肌内血流也发生了重新分配，尽管心肌总血流量减少，但右心室血流量不变。尽管充盈压很高，但右心室每搏功仍降低，而左心室每搏功的降低与低充盈压同时出现。结论是，低输出状态的初始主要原因是肺循环阻力增加，随后是急性右心衰竭。
