Revenäs B, Smedegård G, Arfors K E
Acta Anaesthesiol Scand. 1979 Oct;23(5):435-43. doi: 10.1111/j.1399-6576.1979.tb01472.x.
Aggregate anaphylaxis was induced in seven ovalbumin-sensitized monkeys, with high tires of ovalbumin specific haemagglutinating antibodies. After pretreatment with an intravenous (i.v.) injection of 0.25 mg/kg terbutaline (n = 6) or an infusion of isoprenaline (n = 1), anaphylactic shock was induced by i.v. challenge with specific antigen. Haemodynamics, regional blood flows, respiratory mechanics, blood gases and haematological changes were studied during the following 30 min. Severe shock developed following ovalbumin challenge and the cardiac output was reduced by a mean of 74%. Pulmonary vascular resistance increased 11-fold. Pulmonary dynamic compliance decreased, but there was only a minor increase in pulmonary resistance. Hypoxaemia and severe metabolic acidosis developed. Circulating platelets and leucocytes decreased markedly. Three animals died with fulminant pulmonary oedema. In conclusion, the reaction pattern was similar to that found in studies of monkeys that received no prior treatment. However, the occurrence of pulmonary oedema suggests that the effects of large doses of terbutaline on the heart, combined with the high pulmonary vascular resistance, resulted in more severe pulmonary changes than took place in untreated animals.
在七只对卵清蛋白致敏且具有高滴度卵清蛋白特异性血凝抗体的猴子中诱发了全身性过敏反应。在用0.25mg/kg特布他林静脉注射预处理（n = 6）或异丙肾上腺素输注（n = 1）后，通过静脉注射特异性抗原诱发过敏性休克。在接下来的30分钟内研究血流动力学、局部血流、呼吸力学、血气和血液学变化。卵清蛋白激发后出现严重休克，心输出量平均降低74%。肺血管阻力增加了11倍。肺动态顺应性降低，但肺阻力仅略有增加。出现低氧血症和严重代谢性酸中毒。循环中的血小板和白细胞明显减少。三只动物死于暴发性肺水肿。总之，反应模式与未接受过先前治疗的猴子研究中发现的相似。然而，肺水肿的发生表明大剂量特布他林对心脏的作用，加上高肺血管阻力，导致肺部变化比未治疗的动物更严重。
