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急性双侧肺浸润作为细胞毒性治疗的并发症(作者译)

[Acute bilateral pulmonary infiltration as a complication of cytostatic treatment (author's transl)].

作者信息

Sauer E, Gullotta U, Fink U

出版信息

Dtsch Med Wochenschr. 1975 Oct 10;100(41):2098-101. doi: 10.1055/s-0028-1106507.

Abstract

In three patients on cytostatic drugs acute bilaterally symmetrical pulmonary infiltrates developed. Bacterial, viral or mycotic infections were excluded. The histological findings in the lungs of two had died were those of nonspecific alveolitis. Clinical and radiological findings, as well as the rapid regression of the infiltrates after stopping the cytostatic drugs in the third patient and the marked similarity of the X-ray picture to some similar cases reported in the literature, suggest that these infiltrates resulted from an acute allergic reaction to the cytostatic drugs.

摘要

三名接受细胞毒性药物治疗的患者出现了急性双侧对称性肺部浸润。排除了细菌、病毒或真菌感染。两名已死亡患者肺部的组织学检查结果为非特异性肺泡炎。临床和放射学检查结果,以及第三名患者停用细胞毒性药物后浸润迅速消退,且X线表现与文献中报道的一些类似病例极为相似,提示这些浸润是由对细胞毒性药物的急性过敏反应所致。

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