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通过凝胶过滤法分离松果体提取物。III. 在体外实验中，绵羊松果体因子对小鼠和大鼠下丘脑或垂体前叶的作用

Separation of pineal extracts by gelfiltration. III. Sheep pineal factors acting either on the hypothalamus, or on the anterior hypophysis of mice and rats in in vitro experiments.

作者信息

Ebels I, Citharel A, Moszkowska A

出版信息

J Neural Transm. 1975;36(3-4):281-302. doi: 10.1007/BF01253130.

DOI:10.1007/BF01253130
PMID:1165489
Abstract

Some compounds, other than melatonin, can be detected in aqueous extracts of sheep pineals, using in vitro bioassays. Mild and simple separation methods are used such as gelfiltration on Sephadex G-25, ultrafiltration through Amicon ultramembranes UM-2and UM-05, followed by gelfiltration on Sephadex G-10 and paper electrophoresis. Some fractions are acting on the hypothalamus, others on the anterior hypophysis of mice and rats. The results are compared with those obtained previously with different extraction and separation methods. Key words: Pineal extract, pineal activities in vitro experiments, hypothalamus, anterior hypophysis, paper electrophoresis.

摘要

使用体外生物测定法，可在绵羊松果体的水提取物中检测到除褪黑素之外的一些化合物。采用了温和且简单的分离方法，如在葡聚糖凝胶G - 25上进行凝胶过滤、通过密理博超滤膜UM - 2和UM - 05进行超滤，随后在葡聚糖凝胶G - 10上进行凝胶过滤以及纸电泳。一些组分作用于下丘脑，另一些则作用于小鼠和大鼠的垂体前叶。将这些结果与之前使用不同提取和分离方法所获得的结果进行比较。关键词：松果体提取物、松果体体外实验活性、下丘脑、垂体前叶、纸电泳。

相似文献

1
Separation of pineal extracts by gelfiltration. III. Sheep pineal factors acting either on the hypothalamus, or on the anterior hypophysis of mice and rats in in vitro experiments.通过凝胶过滤法分离松果体提取物。III. 在体外实验中，绵羊松果体因子对小鼠和大鼠下丘脑或垂体前叶的作用
J Neural Transm. 1975;36(3-4):281-302. doi: 10.1007/BF01253130.
2
Separation of pineal extracts by gelfiltration. V. Location by paper chromatography of a sheep pineal principle inhibiting hypophyseal gonadotropic activity.通过凝胶过滤法分离松果体提取物。V. 通过纸色谱法确定绵羊松果体中一种抑制垂体促性腺活性物质的位置。
J Neural Transm. 1976;38(3-4):239-47. doi: 10.1007/BF01249441.
3
A survey of some active sheep pineal fractions and a discussion on the possible significance of pteridines in those fractions in in vitro and in vivo assays.对一些活性绵羊松果体组分的调查以及关于这些组分中蝶啶在体外和体内试验中可能意义的讨论。
J Neural Transm. 1979;44(1-2):97-116. doi: 10.1007/BF01252705.
4
Effects of sheep pineal fractions on the activity of male rat hypothalami in vitro.绵羊松果体提取物对雄性大鼠下丘脑体外活性的影响。
J Neural Transm. 1979;46(1):47-58. doi: 10.1007/BF01243428.
5
Separation of pineal extracts by gelfiltration. VI. Isolation and identification from sheep pineals of biopterin; comparison of the isolated compound with some synthetic pteridines and the biological activity in in vitro and in vivo bioassays.通过凝胶过滤法分离松果体提取物。VI. 从绵羊松果体中分离并鉴定生物蝶呤；将分离出的化合物与一些合成蝶啶进行比较以及体外和体内生物测定中的生物活性。
J Neural Transm. 1977;40(3):205-20. doi: 10.1007/BF01300135.
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Separation of pineal extracts by gelfiltration. I. Isolation from sheep pineals of a substance with special fluorescence characteristics.
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Separation of pineal extracts by gelfiltration. II. Identification and isolation of two indoles from sheep pineal glands.通过凝胶过滤法分离松果体提取物。II. 从绵羊松果体中鉴定和分离出两种吲哚。
J Neural Transm. 1975;36(1):59-69. doi: 10.1007/BF01243438.
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A survey of the location, isolation and identification of indoles, pteridines and some unknown active substances in sheep pineals. The possible significance of pteridines for the neuroendocrine control of neoplastic growth.绵羊松果体中吲哚、蝶啶及一些未知活性物质的定位、分离与鉴定研究。蝶啶对肿瘤生长神经内分泌控制的可能意义。
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9
Separation of pineal extracts by gelfiltration. IV. Isolation, location and identification from sheep pineals of three indoles, identical with 5-hydroxytryptophol, 5-methoxytryptophol and melatonin.通过凝胶过滤法分离松果体提取物。IV. 从绵羊松果体中分离、定位和鉴定三种吲哚，它们与5-羟色醇、5-甲氧基色醇和褪黑素相同。
J Neural Transm. 1976;38(1):31-41. doi: 10.1007/BF01254138.
10
Studies on a high molecular weight luteinizing hormone release stimulating factor of the ovine pineal gland.
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引用本文的文献

1
A survey of the location, isolation and identification of indoles, pteridines and some unknown active substances in sheep pineals. The possible significance of pteridines for the neuroendocrine control of neoplastic growth.绵羊松果体中吲哚、蝶啶及一些未知活性物质的定位、分离与鉴定研究。蝶啶对肿瘤生长神经内分泌控制的可能意义。
J Neural Transm. 1980;49(1-2):87-105. doi: 10.1007/BF01249191.
2
Separation of pineal extracts by gelfiltration. V. Location by paper chromatography of a sheep pineal principle inhibiting hypophyseal gonadotropic activity.通过凝胶过滤法分离松果体提取物。V. 通过纸色谱法确定绵羊松果体中一种抑制垂体促性腺活性物质的位置。
J Neural Transm. 1976;38(3-4):239-47. doi: 10.1007/BF01249441.
3

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Separation of pineal extracts by gelfiltration. VI. Isolation and identification from sheep pineals of biopterin; comparison of the isolated compound with some synthetic pteridines and the biological activity in in vitro and in vivo bioassays.
通过凝胶过滤法分离松果体提取物。VI. 从绵羊松果体中分离并鉴定生物蝶呤；将分离出的化合物与一些合成蝶啶进行比较以及体外和体内生物测定中的生物活性。
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A survey of some active sheep pineal fractions and a discussion on the possible significance of pteridines in those fractions in in vitro and in vivo assays.对一些活性绵羊松果体组分的调查以及关于这些组分中蝶啶在体外和体内试验中可能意义的讨论。
J Neural Transm. 1979;44(1-2):97-116. doi: 10.1007/BF01252705.
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Effects of sheep pineal fractions on the activity of male rat hypothalami in vitro.绵羊松果体提取物对雄性大鼠下丘脑体外活性的影响。
J Neural Transm. 1979;46(1):47-58. doi: 10.1007/BF01243428.
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Ultrastructure of rat pinealocytes in vitro: influence of gonadotropic hormones and LH-RH.体外培养大鼠松果体细胞的超微结构：促性腺激素和促黄体生成激素释放激素的影响
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Radioimmunoassay for rat luteinizing hormone with antiovine LH serum and ovine LH-131-I.
使用抗羊促黄体生成素血清和羊促黄体生成素-131碘进行大鼠促黄体生成素的放射免疫测定。
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