Mestyán J, Soltész G, Schultz K, Horváth M
J Pediatr. 1975 Sep;87(3):409-14. doi: 10.1016/s0022-3476(75)80644-5.
The postnatal (3 to 12 hours) plasma amino acid patterns of normal full-term, nonhypoglycemic, and hypoglycemic small-for-gestational age infants were compared. Seventeen amino acid were separated by automatic column chromatography. It was found that hypoglycemia in SGA newborn infants was associated with a marked increase in total serum amino acid concentrations. This hyperaminoacidemia, which was mainly due to the increase in concentrations of alanine, glycine, proline, and valine, apparently reflected a decreased heapatic gluconeogenic capacity. A significant inverse correlation was observed between concentration of blood glucose and the accumulation of gluconeogenic amino acids. The proportionate accumulation of alanine, glycine, proline, and valine suggests a closely interrelated production and release of these amino acids from the peripheral pools. It is concluded that the changes in concentrations of plasma amino acids occurring in hypoglycemic SGA infants can be helpful in understanding the relative contribution of individual amino acids to gluconeogenesis in the human infant.
对正常足月、非低血糖和低血糖小于胎龄儿出生后（3至12小时）的血浆氨基酸模式进行了比较。通过自动柱色谱法分离出17种氨基酸。发现小于胎龄儿新生儿低血糖与血清总氨基酸浓度显著升高有关。这种高氨基酸血症主要是由于丙氨酸、甘氨酸、脯氨酸和缬氨酸浓度增加，显然反映了肝脏糖异生能力下降。观察到血糖浓度与糖异生氨基酸的积累之间存在显著的负相关。丙氨酸、甘氨酸、脯氨酸和缬氨酸的比例性积累表明这些氨基酸从外周池中产生和释放密切相关。得出的结论是，低血糖小于胎龄儿血浆氨基酸浓度的变化有助于了解个体氨基酸对人类婴儿糖异生的相对贡献。
