四氧嘧啶糖尿病大鼠对化学物质肝毒性反应的增强作用。
Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats.
作者信息
Hanasono G K, Witschi H, Plaa G L
出版信息
Proc Soc Exp Biol Med. 1975 Sep;149(4):903-7. doi: 10.3181/00379727-149-38924.
PMID:1166087
Abstract
Alloxan diabetes enhances the hepatotoxic response of male rats to chloroform and 1, 1, 2-trichloroethane, but not to trichloroethylene nor 1, 1, 1-trichloroethane. Insulin treatment partially protects the animals against the alloxan-induced enhancement of chloroform hepatotoxicity. Alloxan diabetes also enhances the hepatotoxic response to galactosamine but not to beryllium nor alpha-naphthylisothiocyanate.
摘要
四氧嘧啶糖尿病会增强雄性大鼠对氯仿和1,1,2 - 三氯乙烷的肝毒性反应，但对三氯乙烯和1,1,1 - 三氯乙烷则无此作用。胰岛素治疗可部分保护动物免受四氧嘧啶诱导的氯仿肝毒性增强的影响。四氧嘧啶糖尿病还会增强对氨基半乳糖的肝毒性反应，但对铍和α - 萘基异硫氰酸盐则无此作用。
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