Autio-Gold J T, Courts F
University of Florida, College of Dentistry, Department of Operative Dentistry, P.O. Box 100415, Gainesville, Fla. 32610, USA.
J Am Dent Assoc. 2001 Sep;132(9):1247-53; quiz 1317-8. doi: 10.14219/jada.archive.2001.0367.
The aim of this study was to evaluate the effect of fluoride varnish on enamel caries progression in the primary dentition.
One hundred forty-two children in Head Start schools (3 to 5 years old) were randomized into the varnish and control groups. Children in the varnish group received fluoride varnish (Duraphat, Colgate-Palmolive Co.) at baseline and after four months, and children in the control group received no professional fluoride applications. Two calibrated examiners performed the examinations at baseline and at nine months.
At nine months, the authors found that in the control group, 37.8 percent of active enamel lesions on occlusal, buccal and lingual surfaces became inactive, 3.6 percent progressed and 36.9 percent did not change. In the varnish group, 81.2 percent became inactive, 2.4 percent progressed and 8.2 percent did not change. The difference between the groups was statistically significant (P < .0001). The mean decayed surfaces, or ds, value in the varnish group was significantly lower after nine months than it was at baseline (P < .0001). When enamel lesions were included in the data analysis (along with dentinal lesions), the decayed with initial enamel lesions, missing and filled surfaces, or dEmfs, values; decayed with initial enamel lesions, missing and filled teeth, or dEmft, values; and decayed surfaces with initial enamel lesions, or dEs, values were significantly lower in the varnish group after nine months than they were at baseline (P < .0001).
These results suggest that fluoride varnish applications may be an effective measure in reversing active pit-and-fissure enamel lesions in the primary dentition.
Fluoride varnishes are safe, easy to apply and well-accepted by patients. This study shows that fluoride varnish may offer an efficient, nonsurgical alternative for the treatment of decay in children.
本研究的目的是评估氟化物漆对乳牙牙釉质龋进展的影响。
142名就读于启智学校（3至5岁）的儿童被随机分为涂漆组和对照组。涂漆组儿童在基线时和四个月后接受氟化物漆（Duraphat，高露洁棕榄公司），对照组儿童未接受专业的氟化物应用。两名经过校准的检查人员在基线时和九个月时进行检查。
九个月时，作者发现对照组中，咬合面、颊面和舌面的活动性牙釉质病变有37.8%变为非活动性，3.6%进展，36.9%未变化。涂漆组中，81.2%变为非活动性，2.4%进展，8.2%未变化。两组之间的差异具有统计学意义（P < .0001）。九个月后，涂漆组的平均龋坏面（ds）值显著低于基线时（P < .0001）。当将牙釉质病变纳入数据分析（连同牙本质病变）时，九个月后涂漆组中伴有初始牙釉质病变的龋坏、缺失和充填面（dEmfs）值；伴有初始牙釉质病变的龋坏、缺失和充填牙（dEmft）值；以及伴有初始牙釉质病变的龋坏面（dEs）值均显著低于基线时（P < .0001）。
这些结果表明，应用氟化物漆可能是逆转乳牙窝沟牙釉质活动性病变的有效措施。
氟化物漆安全、易于应用且患者接受度良好。本研究表明，氟化物漆可能为儿童龋齿治疗提供一种高效、非手术的替代方法。
