Fischer F, Egg G
Universitäts-HNO-Klinik Innsbruck.
HNO. 1990 Oct;38(10):361-3.
N-acetyl-neuraminic-acid (sialic acid) is a natural component of the cell surface. Cancer cells show a higher concentration of sialic acid in the cell membrane, and the serum also shows an elevated level of sialic acid. The concentration of sialic acid was measured in the serum of 76 new tumour patients and 113 previously treated patients who were clinically free of recurrence. The primary tumour was classified as T1-T4 according to the UICC classification. A further group consisted of patients with recurrent tumours. The values were compared with the sialic acid concentration in the sera of 63 healthy probands. Patients with manifest tumours showed an increased level of sialic acid that correlated with the extent of the tumour. The sialic acid level in 71% of patients with a recurrence lay above the upper limit of normal (82 mg/dl) recorded in the sera of healthy probands. The measurement of the serum sialic acid is a useful parameter for early detection of recurrence.
N-乙酰神经氨酸（唾液酸）是细胞表面的天然成分。癌细胞在细胞膜中显示出较高浓度的唾液酸，血清中唾液酸水平也会升高。对76例新确诊肿瘤患者以及113例临床无复发的既往接受过治疗的患者的血清进行了唾液酸浓度测定。根据国际抗癌联盟（UICC）分类，原发性肿瘤分为T1 - T4期。另一组为复发肿瘤患者。将这些值与63名健康受试者血清中的唾液酸浓度进行比较。有明显肿瘤的患者唾液酸水平升高，且与肿瘤范围相关。71%复发患者的唾液酸水平高于健康受试者血清中记录的正常上限（82毫克/分升）。血清唾液酸测定是早期检测复发的有用参数。
