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关于蜱传脑炎病毒细胞介导免疫反应的体外研究:康复者及人类亚临床感染的研究结果

In vitro studies on cell-mediated immune response to tick-borne encephalitis virus: findings in convalescents and human subclinical infections.

作者信息

Mayer V, Gajdosová E, Slávik I

出版信息

Acta Virol. 1976 Oct;20(5):395-401.

PMID:11667
Abstract

Peripheral blood leukocytes from tick-borne encephalitis (TBE) convelescents (manifest and inapparent forms) working with TBE virus-containing material and from individuals without specific serum virus neutralizing antibodies (VNA) were studied in capillary tube leukocyte migration experiments. Partially purified TBE virus preparations were used as antigen. Under standardized conditions a strong inhibitory reaction was observed in convalescents with significantly higher values in persons recovered from an abortive form of infection only. These results differed markedly from values recorded in persons without specific VNA. Significance of correlation between humoral VNA titres and the intensity of the cell-mediated component of the immune response (CM IR), as indicated by leukocyte migration inhibition (LMI) values, was less than P equals 0.25.

摘要

在毛细管白细胞迁移实验中,对从事含蜱传脑炎(TBE)病毒材料工作的TBE康复者(显性和隐性感染形式)以及无特异性血清病毒中和抗体(VNA)的个体的外周血白细胞进行了研究。部分纯化的TBE病毒制剂用作抗原。在标准化条件下,仅在从感染顿挫型康复的人中观察到强烈的抑制反应,其值明显更高。这些结果与无特异性VNA的个体所记录的值明显不同。体液VNA滴度与免疫反应的细胞介导成分(CM IR)强度之间的相关性(由白细胞迁移抑制(LMI)值表示)的显著性小于P等于0.25。

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