Alm T
Acta Chir Scand. 1975;141(3):218-27.
An investigation of the prevalence of hereditary adenomatosis of the colon and rectum (ACR) in Sweden was started in 1959. Up to the end of 1972, 97 families were traced and 80 of them were more fully investigated. In 56 of the latter families there were at least 2 affected members; in the other 24, only one. In all, 340 affected individuals were found, 150 of whom were operated upon with the aim of cure. Of the operated patients 82 had presented with symptoms, the propositi group, while 68 affected individuals were detected during the family investigations and underwent prophylactic operations, the call-up group. A comparison was made between the two groups of the primary and long-term results after operation. Major surgery with total proctocolectomy and ileostomy (PCI) or colectomy with ileorectal anastomosis (IRA) was performed in 135 cases, 67 propositi and 68 call-up patients; minor surgery with segmental resection (SR) in 15 propositi. The propositi group is presented in detail in this paper, the call-up group in a following paper. In the propositi group there were 3 surgical deaths (3.7%). At the time of operation 48 patients (58.5%), had already developed cancer. Up to the end of the period of observation 16 of them died from metastases, 2 of other malignancies, and 3 of nonmalignant disease.
1959年，瑞典开始了一项关于结肠直肠癌（ACR）遗传腺瘤病患病率的调查。截至1972年底，共追踪到97个家族，其中80个家族接受了更全面的调查。在这80个家族中，有56个家族至少有2名患病成员；另外24个家族只有1名。总共发现了340名患病个体，其中150人接受了旨在治愈的手术。在接受手术的患者中，82人出现了症状，属于先证者组；而68名患病个体是在家族调查中被发现并接受了预防性手术，属于征召组。对两组患者手术后的初期和长期结果进行了比较。135例患者接受了大手术，包括全直肠结肠切除术和回肠造口术（PCI）或结肠切除术加回肠直肠吻合术（IRA），其中67例为先证者，68例为征召患者；15例先证者接受了小手术，即节段性切除术（SR）。本文详细介绍了先证者组，征召组将在后续文章中介绍。先证者组中有3例手术死亡（3.7%）。手术时，48例患者（58.5%）已经发生了癌症。到观察期结束时，其中16人死于转移，2人死于其他恶性肿瘤，3人死于非恶性疾病。
