Zimber-Strobl U, Strobl L J
Institute for Genetics, University of Cologne, 50931 Cologne, Germany.
Semin Cancer Biol. 2001 Dec;11(6):423-34. doi: 10.1006/scbi.2001.0409.
Epstein-Barr virus (EBV) has the ability to immortalize B cells. A viral key protein for immortalization is the transactivator EBNA2 that controls expression of several viral and cellular genes. EBNA2 is tethered to promoters by interacting with the cellular repressor RBP-J. This resembles the physiological activation of RBP-J-repressed promoters by activated Notch receptors (Notch-IC). Since EBNA2 and Notch-IC have been shown to be partially interchangeable in regard to activation of target genes in B cell lines and modulation of differentiation processes it is conceivable that EBNA2 is a biological equivalent of an activated Notch receptor.
爱泼斯坦-巴尔病毒（EBV）具有使B细胞永生化的能力。一种用于永生化的病毒关键蛋白是反式激活因子EBNA2，它控制多种病毒和细胞基因的表达。EBNA2通过与细胞阻遏物RBP-J相互作用而与启动子相连。这类似于活化的Notch受体（Notch-IC）对RBP-J抑制的启动子的生理激活。由于在B细胞系中EBNA2和Notch-IC在靶基因激活和分化过程调节方面已被证明具有部分互换性，因此可以想象EBNA2是活化的Notch受体的生物学等效物。
