苯妥英钠的致畸作用。

Dabee V, Hart A G, Hurley R M

Can Med Assoc J. 1975 Jan 11;112(1):75, 77.

A child aged 24 months had multiple congenital abnormalities and delayed development. The 28-year-old mother had been treated since childhood with anticonvulsants. Her previous pregnancies had resulted in three early spontaneous abortions and one child with severe bilateral cleft lip and palate. This case report further suggests a relationship between maternal diphenylhydantoin use and fetal anomalies.

一名24个月大的儿童患有多种先天性异常且发育迟缓。这位28岁的母亲自童年起就接受抗惊厥药物治疗。她之前的怀孕导致了三次早期自然流产以及一个患有严重双侧唇腭裂的孩子。本病例报告进一步表明母亲使用苯妥英与胎儿异常之间存在关联。