Rader J I, Howard G A, Feist E, Turner R T, Baylink D J
Calcif Tissue Int. 1979 Nov;29(1):21-6. doi: 10.1007/BF02408051.
Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid maturation. Significant decreases in osteoid width and mineralizing front width, as well as a 60% increase in the rate of initial mineralization were observed in the PTE-treated group. Conversion of 3H-25-hydroxyvitamin D3 to 3H-1,25-dihydroxyvitamin D3 was 4-fold higher in the PTE-treated group than in the untreated animals. Increased formation of 1,25-dihydroxyvitamin D3 in response to treatment with PTE may play a major role in correcting the mineralizing defect resulting from thyroparathyroidectomy.
喂食含1.2%钙、0.55%磷饮食的甲状旁腺切除大鼠能维持这些离子的正常血清水平。用甲状旁腺提取物（PTE；20 U/100 g，每日两次；10天）处理此类大鼠，对骨形成速率、基质沉积或类骨质成熟无统计学显著影响。在PTE处理组中观察到类骨质宽度和矿化前沿宽度显著降低，以及初始矿化速率增加60%。PTE处理组中3H-25-羟基维生素D3向3H-1,25-二羟基维生素D3的转化比未处理动物高4倍。PTE处理后1,25-二羟基维生素D3形成增加可能在纠正甲状旁腺切除导致的矿化缺陷中起主要作用。
