• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1,25-二羟基维生素D3对低钙饮食喂养的甲状旁腺切除大鼠骨骼影响的超微结构评估

Ultrastructural evaluation of the effects of 1,25-dihydroxyvitamin D3 on bone of thyroparathyroidectomized rats fed a low-calcium diet.

作者信息

Weisbrode S E, Capen C C, Norman A W

出版信息

Am J Pathol. 1978 Aug;92(2):459-72.

PMID:677270
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2018283/
Abstract

Thyroparathyroidectomized rats fed a low-calcium-normal-phosphorus diet were administered 1 or 5 units of 1,25-dihydroxyvitamin D3-(1,25-[OH]2D3) or placebo daily for 7 days. 1,25-(OH)2D3 elevated serum and urine calcium and decreased serum phosphorus. Rats given 1 unit of 1,25-(OH)2D3 had increased numbers of osteoclasts in metaphyseal trabeculae, Ultrastructurally, osteoclasts, osteoblasts, and osteocytes in rats given 1 unit of 1,25-(OH)2D3, were similar to those in rats given placebo. In rats given 5 units of 1,25-(OH)2D3, osteoclasis was markedly increased. Osteoblasts were more numerous and interpreted to be active in matrix production and mineralization. Lamellated electron-dense bodies were observed adjacent to the plasma membranes of less active osteoblasts and were interpreted to be modified matrix. Most osteocytes in rats given 5 units of 1,25-(OH)2D3 were indistinguishable from osteocytes in rats given placebo. However,the pericellular space of some osteocytes in rats given 5 units of 1,25-(OH)2D3 contained electron-dense granular deposits that were interpreted to be calcium phosphate. It is concluded that 1,25-(OH)2D3 is able to significantly elevate serum calcium independent of dietary calcium, parathyroid hormone, and calcitonin primarily by increasing ostoeclasis with minimal dependence on osteocytic osteolysis.

摘要

给甲状旁腺切除的大鼠喂食低钙 - 正常磷饮食，每天给予1或5单位的1,25 - 二羟基维生素D3 -（1,25 - [OH]2D3）或安慰剂，持续7天。1,25 -（OH）2D3可提高血清和尿钙水平，并降低血清磷水平。给予1单位1,25 -（OH）2D3的大鼠干骺端小梁中的破骨细胞数量增加。超微结构上，给予1单位1,25 -（OH）2D3的大鼠中的破骨细胞、成骨细胞和骨细胞与给予安慰剂的大鼠中的相似。给予5单位1,25 -（OH）2D3的大鼠中，骨吸收明显增加。成骨细胞数量更多，被认为在基质产生和矿化方面活跃。在活性较低的成骨细胞质膜附近观察到层状电子致密体，被认为是修饰后的基质。给予5单位1,25 -（OH）2D3的大鼠中的大多数骨细胞与给予安慰剂的大鼠中的骨细胞无法区分。然而，给予5单位1,25 -（OH）2D3的大鼠中一些骨细胞的细胞周隙含有电子致密颗粒沉积物，被认为是磷酸钙。结论是，1,25 -（OH）2D3能够在不依赖膳食钙、甲状旁腺激素和降钙素的情况下显著提高血清钙水平，主要是通过增加骨吸收，对骨细胞性骨溶解的依赖性最小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/66a6d3657b44/amjpathol00736-0156-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/47e28228c09b/amjpathol00736-0152-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/eded204fc284/amjpathol00736-0153-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/896e5c22640b/amjpathol00736-0153-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/1cefcb164ea3/amjpathol00736-0153-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/ee3b5f6e824d/amjpathol00736-0155-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/bcc13aed99c3/amjpathol00736-0155-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/d98ae3b35126/amjpathol00736-0155-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/3a00fc949e41/amjpathol00736-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/29a18cc3115c/amjpathol00736-0151-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/ecb3908f919a/amjpathol00736-0156-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/66a6d3657b44/amjpathol00736-0156-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/47e28228c09b/amjpathol00736-0152-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/eded204fc284/amjpathol00736-0153-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/896e5c22640b/amjpathol00736-0153-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/1cefcb164ea3/amjpathol00736-0153-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/ee3b5f6e824d/amjpathol00736-0155-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/bcc13aed99c3/amjpathol00736-0155-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/d98ae3b35126/amjpathol00736-0155-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/3a00fc949e41/amjpathol00736-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/29a18cc3115c/amjpathol00736-0151-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/ecb3908f919a/amjpathol00736-0156-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe69/2018283/66a6d3657b44/amjpathol00736-0156-b.jpg

相似文献

1
Ultrastructural evaluation of the effects of 1,25-dihydroxyvitamin D3 on bone of thyroparathyroidectomized rats fed a low-calcium diet.1,25-二羟基维生素D3对低钙饮食喂养的甲状旁腺切除大鼠骨骼影响的超微结构评估
Am J Pathol. 1978 Aug;92(2):459-72.
2
Light- and electron-microscopic evaluation of the effects of 1,25-dihydroxyvitamin D3 on bone of thyroparathyroidectomized rats.
Am J Pathol. 1979 Nov;97(2):247-60.
3
The ultrastructural effect of estrogens on bone cells in thyroparathyroidectomized rats.雌激素对甲状腺甲状旁腺切除大鼠骨细胞的超微结构影响。
Am J Pathol. 1977 May;87(2):311-22.
4
Effects of parathyroid hormone on bone of thyroparathyroidectomized rats: an ultrastructural and enzymatic study.甲状旁腺激素对甲状腺甲状旁腺切除大鼠骨骼的影响：一项超微结构和酶学研究。
Am J Pathol. 1974 Jun;75(3):529-41.
5
Ultrastructural evaluation of the interaction of glucocorticoids and vitamin D on bone cells in thyroparathyroidectomized rats.甲状腺甲状旁腺切除大鼠中糖皮质激素与维生素D对骨细胞相互作用的超微结构评估
Am J Pathol. 1976 Sep;84(3):457-68.
6
Effect of dietary calcium on the response of bone to 1,25 (OH)2D3.
Lab Invest. 1983 Jun;48(6):683-9.
7
Ultrastructural development of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.
Bone. 1985;6(3):165-72. doi: 10.1016/8756-3282(85)90049-3.
8
The action of vitamin D metabolites (25 OHD3--12,5 (OH)2D3--24.25 (OH)2D3--25.26 (OH)2D3) on vitamin D deficient rats.维生素D代谢产物（25羟胆钙化醇——1,25二羟胆钙化醇——24,25二羟胆钙化醇——25,26二羟胆钙化醇）对维生素D缺乏大鼠的作用。
Biomedicine. 1978 Jul-Aug;28(4):237-42.
9
Interaction of dichloromethylene diphosphonate and vitamin D on bone of thyroparathyroidectomized rats.二氯亚甲基二膦酸盐与维生素D对甲状腺甲状旁腺切除大鼠骨骼的相互作用
Am J Pathol. 1977 Oct;89(1):137-52.
10
Ultrastructural immunocytochemical localization of endogenous 1,25-dihydroxyvitamin D3 and its receptors in osteoblasts and osteocytes from neonatal mouse and rat calvaria.新生小鼠和大鼠颅骨成骨细胞及骨细胞内源性1,25 - 二羟维生素D3及其受体的超微结构免疫细胞化学定位
Bone Miner. 1987 Nov;3(2):125-36.

引用本文的文献

1
Vitamin D and orthodontics: an insight review.维生素D与正畸学：综述
Clin Cosmet Investig Dent. 2018 Jul 30;10:165-170. doi: 10.2147/CCIDE.S157840. eCollection 2018.
2
Osteoclast formation in response to intraperitoneal injection of 1 alpha-hydroxycholecalciferol in mice.小鼠腹腔注射1α-羟基胆钙化醇后破骨细胞的形成
J Anat. 1981 Aug;133(Pt 1):91-7.
3
Histomorphometric evaluation of the effects of intermittent 1,25-dihydroxycholecalciferol administration on cortical bone remodeling in adult dogs.间歇性给予1,25-二羟胆钙化醇对成年犬皮质骨重塑影响的组织形态计量学评估

本文引用的文献

1
EXPERIMENTAL NEPHROCALCINOSIS. A BIOCHEMICAL AND MORPHOLOGIC STUDY.实验性肾钙质沉着症。一项生物化学与形态学研究。
Lab Invest. 1965 Feb;14:123-41.
2
A STUDY OF METASTATIC RENAL CALCIFICATION AT THE CELLULAR LEVEL.细胞水平转移性肾钙化的研究
J Cell Biol. 1964 Jul;22(1):189-206. doi: 10.1083/jcb.22.1.189.
3
ELECTRON MICROSCOPIC STUDY OF RENAL CALCIFICATION.肾钙化的电子显微镜研究
Am J Pathol. 1981 Jul;104(1):41-9.
4
Continuous infusion of 1,25-dihydroxyvitamin D3 stimulates bone turnover in the normal young mouse.持续输注1,25 - 二羟维生素D3可刺激正常幼鼠的骨转换。
Calcif Tissue Int. 1983 Jul;35(4-5):418-25. doi: 10.1007/BF02405070.
5
24,25(OH)2D3, bone formation, and bone resorption in vitamin D-deficient, azotemic rats.维生素D缺乏的氮质血症大鼠体内的24,25(OH)2D3、骨形成与骨吸收
Calcif Tissue Int. 1984 Mar;36(2):206-13. doi: 10.1007/BF02405319.
6
Short-term effects of vitamin D3 and 1,25-dihydroxyvitamin D3 on osteomalacia in uremic rats fed a low calcium-low-phosphorus diet.维生素D3和1,25-二羟基维生素D3对低钙低磷饮食喂养的尿毒症大鼠骨软化症的短期影响。
Am J Pathol. 1981 Jul;104(1):35-40.
7
Histological observations on the failure of rachitic rat bones to respond to 1,25/OH)2D3.佝偻病大鼠骨骼对1,25-(OH)₂D₃无反应的组织学观察
Calcif Tissue Int. 1980;31(3):215-23. doi: 10.1007/BF02407184.
8
1,25-Dihydroxyvitamin D3 causes an increase in the number of osteoclastlike cells in cat bone marrow cultures.1,25-二羟维生素D3可使猫骨髓培养物中破骨细胞样细胞数量增加。
Calcif Tissue Int. 1985 May;37(3):276-81. doi: 10.1007/BF02554874.
9
Inhibition by aminohydroxypropylidene bisphosphonate (AHPrBP) of 1,25(OH)2 vitamin D3-induced stimulated bone turnover in the mouse.
Calcif Tissue Int. 1985 May;37(3):268-75. doi: 10.1007/BF02554873.
10
Light- and electron-microscopic evaluation of the effects of 1,25-dihydroxyvitamin D3 on bone of thyroparathyroidectomized rats.
Am J Pathol. 1979 Nov;97(2):247-60.
Am J Pathol. 1964 Mar;44(3):365-81.
4
THE RELATIONSHIP BETWEEN VITAMIN D AND PARATHYROID HORMONE.维生素D与甲状旁腺激素之间的关系。
J Clin Invest. 1963 Dec;42(12):1940-6. doi: 10.1172/JCI104880.
5
Electron microscopical and microprobe observations on the cell sheath of stimulated osteocytes.对受刺激骨细胞细胞鞘的电子显微镜和微探针观察。
Calcif Tissue Res. 1969 Aug 11;4(1):60-8. doi: 10.1007/BF02279106.
6
1,25-Dihydroxycholecalciferol--a hormonally active form of vitamin D.
Recent Prog Horm Res. 1974;30(0):431-80.
7
Regulation of 25-hydroxycholecalciferol-1-hydroxylase activity in kidney by parathyroid hormone.甲状旁腺激素对肾脏中25-羟胆钙化醇-1-羟化酶活性的调节
Nat New Biol. 1973 Feb 7;241(110):163-6. doi: 10.1038/newbio241163a0.
8
Control of 25-hydroxycholecalciferol metabolism by parathyroid glands.甲状旁腺对25-羟胆钙化醇代谢的调控。
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1673-6. doi: 10.1073/pnas.69.7.1673.
9
Parathyroid hormone as a trophic hormone for 1,25-dihydroxyvitamin D3, the metabolically active form of vitamin D.甲状旁腺激素作为1,25 - 二羟维生素D3（维生素D的代谢活性形式）的促生长激素。
N Engl J Med. 1972 Aug 3;287(5):250-1. doi: 10.1056/NEJM197208032870511.
10
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture.1,25-二羟胆钙化醇：组织培养中骨吸收的强效刺激剂。
Science. 1972 Feb 18;175(4023):768-9. doi: 10.1126/science.175.4023.768.