Uematsu H, Dougherty L, Takahashi M, Ohno Y, Nakatsu M, Song H K, Ferrari V A, Gefter W B, Schnall M D, Hatabu H
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-2649, USA.
Magn Reson Med. 2001 Nov;46(5):1028-30. doi: 10.1002/mrm.1292.
In this study, pulmonary MR angiography (MRA) using a tailored coil at 4 Tesla in conjunction with an intravenous injection of contrast agent is described. Three-dimensional gradient-echo images were obtained during the intravenous injection of 0.05, 0.1, and 0.2 mmol/kg body weight of gadodiamide to investigate the signal enhancement effect of the contrast agent in pulmonary arteries qualitatively and quantitatively. In the qualitative analysis, the subsegmental branches were visualized on every dose. In the quantitative analysis, the average contrast-to-noise ratios (CNRs) of the main pulmonary arteries increased in a dose-dependent manner. However, the CNRs of segmental arteries did not increase as the dose of contrast agent increased, as observed at 1.5 Tesla MRI. These observations demonstrate the feasibility of delineating the pulmonary vasculature using a contrast agent; however, our results also suggest possible high-field-related disabilities that need to be overcome before high-field (> or =4 Tesla) MRI can be used to full advantage.
本研究描述了在4特斯拉场强下使用定制线圈并结合静脉注射造影剂进行肺部磁共振血管造影（MRA）的方法。在静脉注射钆双胺，剂量分别为0.05、0.1和0.2 mmol/kg体重时，采集三维梯度回波图像，以定性和定量研究造影剂对肺动脉的信号增强效果。在定性分析中，各剂量下均能观察到亚段分支。在定量分析中，主肺动脉的平均对比噪声比（CNR）呈剂量依赖性增加。然而，与1.5特斯拉MRI观察结果相同，随着造影剂剂量增加，段动脉的CNR并未增加。这些观察结果证明了使用造影剂描绘肺血管系统的可行性；然而，我们的结果也表明，在高场（≥4特斯拉）MRI能够充分发挥优势之前，可能存在一些与高场相关的问题需要克服。
