Frankevich V, Zenobi R
Department of Chemistry, Swiss Federal Institute of Technology, ETH Hönggerberg, CH-8093 Zürich, Switzerland.
Rapid Commun Mass Spectrom. 2001;15(21):2035-40. doi: 10.1002/rcm.474.
A new method of ion deceleration in a Fourier transform ion cyclotron resonance (FTICR) open cell is described that improves the performance of FTICR-MS instruments equipped with an internal source for laser desorption/ionization. Ion deceleration occurs in the front trapping cylinder of an open cylindrical cell. Decelerating voltages up to 100 V can be applied for 10-500 micros to the front cylinder during ion introduction. The deceleration field is uniformly distributed along the cylinder length giving a "smooth" deceleration, which means that the deceleration is effective over a large time interval and a large m/z range. This results in improved trapping efficiency of high-energy ions. We demonstrate efficient trapping of high (m/z 66 kDa) mass ions and the possibility to reduce the width of the kinetic energy distribution of MALDI ions with this arrangement.
描述了一种在傅里叶变换离子回旋共振（FTICR）开放式池中进行离子减速的新方法，该方法提高了配备激光解吸/电离内部源的FTICR-MS仪器的性能。离子减速发生在开放式圆柱形池的前捕获圆筒中。在离子引入期间，可在前圆筒上施加高达100 V的减速电压，持续10 - 500微秒。减速场沿圆筒长度均匀分布，实现“平滑”减速，这意味着减速在较大的时间间隔和较大的m/z范围内有效。这导致高能离子的捕获效率提高。我们证明了利用这种装置能够高效捕获高质量（m/z 66 kDa）离子，并有可能减小基质辅助激光解吸电离（MALDI）离子动能分布的宽度。
