Swenberg J A, Koestner A, Wechsler W, Brunden M N, Abe H
J Natl Cancer Inst. 1975 Jan;54(1):89-96. doi: 10.1093/jnci/54.1.89.
We investigated differences in the oncogenic effects of methylnitrosourea (MNU) which were induced by varying dose schedules and changing administration routes. The nervous system represented the target organ when MNU was given intravenously to rats. Carcinogen by other routes resulted in decreased numbers of neurogenic tumors and the appearance of neoplasms at the injection site. Increased oral doses of MNU caused shorter survival times, a decreased incidence of neuroglial tumors, and increased numbers of thymic lymphomas and mesenchymal tumors of the nervous system. The results suggest that many tissues are susceptible to the oncogenic effects of MNU, but the degree of exposure necessary for neoplastic transformation varies.
我们研究了不同剂量方案和给药途径诱导的甲基亚硝基脲（MNU）致癌作用的差异。当给大鼠静脉注射MNU时，神经系统是靶器官。通过其他途径给予致癌物会导致神经源性肿瘤数量减少以及注射部位出现肿瘤。口服MNU剂量增加会导致生存时间缩短、神经胶质瘤发病率降低以及胸腺淋巴瘤和神经系统间叶性肿瘤数量增加。结果表明，许多组织对MNU的致癌作用敏感，但肿瘤转化所需的暴露程度各不相同。
