通过连续口服N-丁基-N-亚硝基脲诱导F344大鼠消化道肿瘤
Induction of digestive-tract tumors in F344 rats by continuous oral administration of N-butyl-N-nitrosourea.
作者信息
Takeuchi M, Ogiu T, Matsuoka C, Furuta K, Maekawa A, Nakadate M, Odashima S
出版信息
J Cancer Res Clin Oncol. 1984;107(1):32-7. doi: 10.1007/BF00395487.
Male and female F344/DuCrj rats were administered N-butyl-N-nitrosourea at a concentration of 400 ppm in their drinking water. By the 50th week of the experiment, the cumulative incidence of upper-digestive-tract tumors was as high as 35/39 (90%) and 34/39 (87%) in male and female rats, respectively. Among these, esophageal and forestomach tumors occurred most frequently. Except one female rat with fibroma, upper-digestive-tract neoplasms were of the epithelial type -- papilloma, squamous-cell carcinoma or adenocarcinoma. In female rats, vaginal tumors were induced in 16 (41%) animals. Ear-duct tumors and hematopoietic neoplasms were also induced in both sexes of rats, with incidence of less than 21%.
将雄性和雌性F344/DuCrj大鼠置于含浓度为400 ppm N-丁基-N-亚硝基脲的饮用水中。到实验第50周时，雄性和雌性大鼠上消化道肿瘤的累积发生率分别高达35/39（90%）和34/39（87%）。其中，食管和前胃肿瘤最为常见。除一只患有纤维瘤的雌性大鼠外，上消化道肿瘤均为上皮类型——乳头状瘤、鳞状细胞癌或腺癌。在雌性大鼠中，16只（41%）出现阴道肿瘤。大鼠两性均诱发了耳道肿瘤和造血系统肿瘤，发生率低于21%。
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