Lijinsky W, Reuber M D, Blackwell B N
J Natl Cancer Inst. 1980 Aug;65(2):451-3.
Three nitrosotrialkylureas were administered to female F344 rats as approximately 1-mM solutions in drinking water. Nitrosotrimethylurea, given for 47 weeks, gave rise to astrocytomas of the brain and tumors of the forestomach; nitrosotriethylurea induced a high incidence of adenocarcinomas of the breast and uterus and tumors of the forestomach. Nitrosomethyldiethylurea induced almost exclusively a high incidence of both astrocytomas of the brain and tumors of the spinal cord.
将三种亚硝基三烷基脲以约1毫摩尔的溶液形式加入到雌性F344大鼠的饮用水中。给予亚硝基三甲基脲47周后，引发了脑星形细胞瘤和前胃肿瘤；亚硝基三乙基脲诱发了高比例的乳腺癌、子宫癌和前胃肿瘤。亚硝基甲基二乙基脲几乎仅诱发了高比例的脑星形细胞瘤和脊髓肿瘤。
