Forsberg J G
Am J Obstet Gynecol. 1975 Jan 1;121(1):101-4. doi: 10.1016/0002-9378(75)90983-7.
Diethylstilbestrol, 5 mug per day for the first 5 days after birth, was injected into neonatal female NMRI mice. The animals were killed 13 months after birth. The upper vaginal part and the uterine cervix were serially sectioned. The histologic study showed extensive adenosis comprising most of the cervical wall. In some regions the glandular epithelium had undergone epidermatization. There were suggestive evidences of cancerous development from both the glandular epithelium and the epithelium in the epidermized regions. In the vaginal part, the squamous epithelium showed hyperplasia, but there were also glandular ducts penetrating far into the subepithelial tissue.
己烯雌酚，在新生雌性NMRI小鼠出生后的头5天每天注射5微克。动物在出生13个月后处死。对阴道上段和子宫颈进行连续切片。组织学研究显示广泛的腺病，累及大部分宫颈壁。在一些区域，腺上皮已发生表皮化生。有迹象表明腺上皮和表皮化生区域的上皮均有癌变发展。在阴道部分，鳞状上皮显示增生，但也有腺管深入到上皮下组织。
