New acetophenone glucosides isolated from extracts of Helichrysum italicum with antiinflammatory activity.

作者信息

Sala A, Recio M C, Giner R M, Máñez S, Ríos J L

机构信息

Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.

出版信息

J Nat Prod. 2001 Oct;64(10):1360-2. doi: 10.1021/np010125x.

DOI:10.1021/np010125x

PMID:11678669

Abstract

Three new acetophenone glucosides (4-6), three known aglycons (1-3), and a benzo-gamma-pyrone glucoside (7) were isolated from the CH(2)Cl(2), EtOAc, and BuOH extracts from the aerial parts of Helichrysum italicum. All the compounds tested showed antiinflammatory activity in a 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse ear edema test, and the ID(50) value of compound 2, the most active compound, was determined.

摘要