Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, via Vivaldi 43, 81100 Caserta, Italy.
Bioorg Med Chem. 2013 Nov 15;21(22):7038-46. doi: 10.1016/j.bmc.2013.09.019. Epub 2013 Sep 18.
Two new acylated styrylpyrones, one 5-methoxy-1(3H)-isobenzofuranone glucoside and a hydroxymethyl-orcinol derivative, along with sixteen known aromatic metabolites, including lignans, quinic acid derivatives low-molecular weight phenol glucosides, have been isolated from the methanol extract of Helichrysum italicum, a medicinal plant typical of the Mediterranean vegetation. The structures of these compounds have been elucidated on the basis of extensive 2D-NMR spectroscopic analyses, including COSY, TOCSY, HSQC, CIGAR-HMBC, H2BC and HSQC-TOCSY, along with Q-TOF HRMS(2) analysis. Selected compounds were evaluated for their anti-biofilm properties against Pseudomonas aeruginosa.
从典型地中海植被药用植物 Helichrysum italicum 的甲醇提取物中分离得到两种新的酰化苯乙烯基吡喃酮，一种是 5-甲氧基-1(3H)-异苯并呋喃酮葡萄糖苷和一个羟甲基-间苯二酚衍生物，以及十六种已知的芳香族代谢物，包括木脂素、奎尼酸衍生物、低分子量酚葡萄糖苷。基于广泛的二维 NMR 光谱分析，包括 COSY、TOCSY、HSQC、CIGAR-HMBC、H2BC 和 HSQC-TOCSY，以及 Q-TOF HRMS(2)分析，确定了这些化合物的结构。对选定的化合物进行了抗假单胞菌生物膜特性的评估。
