锂的使用与寂静性甲状腺炎所致甲状腺毒症之间的关联。

Association between lithium use and thyrotoxicosis caused by silent thyroiditis.

作者信息

Miller K K, Daniels G H

机构信息

Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

出版信息

Clin Endocrinol (Oxf). 2001 Oct;55(4):501-8. doi: 10.1046/j.1365-2265.2001.01381.x.

DOI:10.1046/j.1365-2265.2001.01381.x

PMID:11678833

Abstract

OBJECTIVE

To determine the incidence of silent thyroiditis in lithium users and characterize lithium-associated thyrotoxicosis.

DESIGN

Retrospective record review.

PATIENTS

400 consecutive patients (300 with Graves' disease and 100 with silent thyroiditis) who underwent radioiodine scanning of the thyroid.

MEASUREMENTS

Odds of lithium exposure.

RESULTS

The odds of lithium exposure were increased 4.7-fold in patients with silent thyroiditis compared with those with Graves' disease (95% CI: 1.3, 17). Lithium-associated silent thyroiditis occurred with an incidence rate of approximately 1.3 cases per 1000 person-years, and lithium-associated thyrotoxicosis occurred with an incidence rate of approximately 2.7 cases per 1000 person-years, higher than the reported incidence rates of silent thyroiditis (< 0.03-0.28 cases per 1000 person-years) and of thyrotoxicosis (0.8-1.2 cases per 1000 person-years) in the general population.

CONCLUSION

Thyrotoxicosis caused by silent thyroiditis might be associated with lithium use.

摘要

目的

确定锂使用者中无症状性甲状腺炎的发病率，并描述锂相关甲状腺毒症的特征。

设计

回顾性记录审查。

患者

400例连续接受甲状腺放射性碘扫描的患者（300例格雷夫斯病患者和100例无症状性甲状腺炎患者）。

测量

锂暴露的比值比。

结果

与格雷夫斯病患者相比，无症状性甲状腺炎患者的锂暴露比值比增加了4.7倍（95%可信区间：1.3，17）。锂相关无症状性甲状腺炎的发病率约为每1000人年1.3例，锂相关甲状腺毒症的发病率约为每1000人年2.7例，高于一般人群中无症状性甲状腺炎（每1000人年<0.03 - 0.28例）和甲状腺毒症（每1000人年0.8 - 1.2例）的报告发病率。