Mizukami Y, Michigishi T, Nonomura A, Nakamura S, Noguchi M, Takazakura E
Kanazawa University Hospital, Japan.
J Clin Pathol. 1995 Jun;48(6):582-4. doi: 10.1136/jcp.48.6.582.
A 26 year old woman with lithium induced thyrotoxicosis is reported. The thyrotoxicosis was associated with a non-tender diffuse goitre and a low radioiodine uptake by the gland. The thyrotoxicosis was reversible and remitted on withdrawal of the drug. The histopathological alterations of the thyroid glad were characterised by extensive follicular cell disruption with no lymphocytic infiltration. It is postulated that lithium might directly damage thyroid follicular cells and that subsequent release of thyroglobulin into the circulation might be a cause of transient thyrotoxicosis.
报告了一名26岁患有锂诱导甲状腺毒症的女性。该甲状腺毒症伴有非压痛性弥漫性甲状腺肿，且甲状腺摄碘率低。甲状腺毒症是可逆的，停药后缓解。甲状腺组织病理学改变的特征是广泛的滤泡细胞破坏，无淋巴细胞浸润。据推测，锂可能直接损害甲状腺滤泡细胞，随后甲状腺球蛋白释放入血可能是短暂性甲状腺毒症的一个原因。
