Department of Paediatric Gastroenterology, University Hospitals Leuven, Leuven, Belgium.
Neurogastroenterol Motil. 2012 Feb;24(2):108-12, e81. doi: 10.1111/j.1365-2982.2011.01813.x. Epub 2011 Nov 21.
The aim was to compare gastric emptying rate and nutrient tolerance during a satiety drinking test in children with functional dyspepsia (FD) and obesity and to study the relationship between daily caloric intake and the satiety drinking test.
A total of 28 dyspeptic children (22 girls, mean age 12.5 ± 3.1 years) and 15 obese children (five girls, 13.3 ± 1.8 years) were studied. The patients underwent an octanoic acid gastric emptying breath test and a satiety drinking test. Prior to both tests, a dyspepsia questionnaire was filled out to calculate the mean calorie intake.
The most prevalent dyspeptic symptoms were early satiety (96.4%), postprandial fullness (89.2%), and epigastric pain (78.6%), followed by nausea (50%). All dyspeptic and obese children (n = 43) started the satiety drinking test and 41 children completed the test until a score of 5 was reached. The maximum ingested volume in FD was significantly lower than in obesity or in age-matched healthy controls (252 ± 85 vs 479 ± 199 and 359 ± 29 mL respectively, both P < 0.05). As a group, dyspeptic children had significantly slower gastric emptying than obese children (89.7 ± 54.8 min vs 72.5 ± 26.0 min, P = 0.05). Daily calorie intake was significantly higher in obese children than that in dyspeptic children (2325 ± 469 vs 1503 ± 272 cal, P < 0.0001). The endpoint of the satiety drinking test was significantly correlated with body weight or BMI (both R = 0.41, P = 0.04), but not with daily calorie intake, gastric emptying rate or age.
CONCLUSIONS & INFERENCES: The satiety drinking test is a potentially useful non-invasive tool in the investigation of children with FD and obesity.
本研究旨在比较功能性消化不良（FD）和肥胖儿童在饱腹感饮料测试中的胃排空率和营养耐受性，并研究每日热量摄入与饱腹感饮料测试之间的关系。
共纳入 28 例消化不良儿童（22 名女性，平均年龄 12.5 ± 3.1 岁）和 15 例肥胖儿童（5 名女性，13.3 ± 1.8 岁）。患者接受辛酸胃排空呼吸试验和饱腹感饮料测试。在这两项测试之前，填写消化不良问卷以计算平均热量摄入。
最常见的消化不良症状为早饱（96.4%）、餐后饱胀（89.2%）和上腹痛（78.6%），其次为恶心（50%）。所有消化不良和肥胖儿童（n=43）均开始进行饱腹感饮料测试，41 名儿童完成测试直至达到 5 分。FD 组的最大摄入容量明显低于肥胖组或年龄匹配的健康对照组（分别为 252 ± 85、479 ± 199 和 359 ± 29 mL，均 P < 0.05）。作为一个整体，消化不良儿童的胃排空速度明显慢于肥胖儿童（89.7 ± 54.8 min 与 72.5 ± 26.0 min，P = 0.05）。肥胖儿童的每日热量摄入明显高于消化不良儿童（2325 ± 469 与 1503 ± 272 cal，P < 0.0001）。饱腹感饮料测试的终点与体重或 BMI 呈显著相关（均 R = 0.41，P = 0.04），但与每日热量摄入、胃排空率或年龄无关。
饱腹感饮料测试是一种有潜力的非侵入性工具，可用于研究 FD 和肥胖儿童。
